Combine effect of tab melatonin and pectointercostal fascial block on postoperative pain management in patients undergoing open heart surgeries.

Phase 2

Conditions: Health Condition 1: O- Medical and Surgical

Registration Number: CTRI/2024/05/067707

Lead Sponsor: AIIMS Raipur

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

Adult patients aged 18-to-80 years -ASA grades II- to-III -Patients scheduled for elective on-pump cardiac surgery requiring median sternotomies such

as coronary artery bypass grafting (CABG), CABG with or without valve replacement, and

isolated valve surgeries will include in the study.

Exclusion Criteria

-emergency surgery, -an allergy to local anaesthetics, -hemodynamic instability (left ventricular ejection fraction & EF 30%) -congestive heart failure, hepatic or renal failure, -a history of drug abuse or chronic pain, -psychiatric problems, -secondary surgery, - inability to provide inform

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess whether the combination of melatonin and B/L <br/ ><br>pectointercostal fascial block provides prolonged adequate analgesia and promotes rapid <br/ ><br>recovery.Timepoint: numeric rating scale (NRS) at 0, 3, 6-, 12-, 18-, and 24-hours during breathing of normal tidal <br/ ><br>volume and with cough.

Secondary Outcome Measures

Name	Time	Method
The requirement of fentanyl during the postoperative period, <br/ ><br>extubation time, postoperative delirium and length of ICU, and hospital stay. <br/ ><br>To evaluate anxiety and sedation levels in the preoperative area before shifting to the <br/ ><br>9 <br/ ><br>operation theatre.Timepoint: preoperative, postoperatively 24 hrs