Effect of Exercise Intervention on Various Physiologic Factors That Change With Increasing Age

Not Applicable

Completed

• Conditions: Aging

• Registration Number: NCT00283673
• Lead Sponsor: Mayo Clinic

Brief Summary

This study randomized healthy sedentary people age 20-80 years to 16 weeks of supervised exercise versus no exercise. Several end points were evaluated after 16 weeks including insulin sensitivity and muscle physiology.

Detailed Description

Healthy subjects performing \< 30 min exercise twice per week were studied prior to randomization and after of sixteen weeks exercise. They were randomized to sixteen weeks of supervised exercise performed on a stationary bike vs. placebo exercise (a series of flexibility exercises performed at home). Intensity, duration and frequency of exercise were gradually increased to four sessions per week lasting forty minutes each and achieving 80% target heart rate. Participants were weighed perioidically and counseled appropriately when weight changed by \> 2 %. Insulin sensitivity and muscle mitochondrial protein synthesis were studied.

Study Timeline

• Study Start: 1995-09
• Primary Completion: 1998-01
• Study Completion: 1998-01
• Study First Submitted: 2006-01-27
• Study First Submitted QC: 2006-01-27
• Study First Posted: 2006-01-30
• Status Verified: 2011-06
• Last Update Submitted: 2011-06-03
• Last Update Posted: 2011-06-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Insulin sensitivity

Secondary Outcome Measures

Name	Time	Method
Muscle Mitochondrial Protein Synthesis
mRNA of mitochondrial genes
mRNA of genes involved in mitochondrial biogenesis

Trial Locations

Locations (1)

Mayo Clinic; 🇺🇸 Rochester, Minnesota, United States