The effect of periodontitis on innate immune activation and vascular wall inflammation in relation with atherosclerosis
- Conditions
- parodontitisGum disease10003216
- Registration Number
- NL-OMON44156
- Lead Sponsor
- Radboud Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
- Age between 40 and 80 years
- With or without severe periodontitis with DPSI score of 0-2 resp. 4
- Written informed consent
- Cardiovascular events
- Diabetes mellitus
- Chronic infections other than periodontitis
- Medical history of any disease associated with immune deficiency (either congenital or acquired, including chemotherapy, chronic steroid use, organ transplant)
- Fever (T > 38.5) or antibiotics use for infectious disease within 1 month prior study entry
- Chronic use of anti-inflammatory drugs such as NSAIDs
- Recent hospital admission or surgery with general anaesthesia (< 3 months)
- Known heart failure, chronic kidney (MDRD <45 ml/min) or liver disease (ALAT more than three times upper reference limit or known liver disease)
- Inability to personally provide written informed consent (e.g. for linguistic or mental reasons)
- Inability to undergo PET-CT scanning, including pregnancy
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter will be to correlate tissue inflammation, measured by<br /><br>TBR max with 18F-FDG on PET-CT scanning of periodontal tissue with the vascular<br /><br>wall, spleen and bone marrow in patients with versus without periodontal<br /><br>disease.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The cytokine/chemokine response to ex vivo stimulation of the innate immune<br /><br>cells in patients with versus without periodontal disease.</p><br>