The impact of gender differences in P-glycoprotein function measured with [18F]MC225 and PET

• Conditions: transporterfunctie op de bloed-hersenbarriere; genderdifferences

• Registration Number: NL-OMON53850
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

- Age: 50-80 years
- MMSE: 28-30
- No history of any neuropsychiatric disorders that might affect the P-gp
function or blood-brain barrier integrity

Exclusion Criteria

- Use of medication with known P-gp affinity
- History of neuropsychiatric disorders affecting the P-gp function or
blood-brain barrier integrity

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>PET images will be analysed using PMOD software (PMOD technologies, Zurich,<br /><br>Switzerland, version 4.1). Predefined brain regions based on a maximum<br /><br>probability map are selected as volumes of interest (VOIs). Tracer kinetics of<br /><br>[18F]MC225 reflect the BBB P-gp function and will be assessed as outcome<br /><br>measure for P-gp efflux function. Those will be compared in between the groups<br /><br>of male and female subjects.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>