Peribulbar and Subconjunctival Kenalog Injection for Thyroid Orbitopathy
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 主要终点
- Comparing the effectiveness of subconjunctival and peribulbar Triamcinolone injection to systemic Steroid therapy for patients with active thyroid orbitopathy .
研究概览
简要总结
Comparing the effectiveness of subconjunctival and peribulbar Triamcinolone injection to systemic Steroid therapy for patients with active thyroid orbitopathy.
详细描述
Local Steroid treatment may help in active thyroid orbitopathy. till today, systemic Steroids are the treatment for active thyroid orbitopathy which is associated with systemic adverse effects.
In this study the investigators want to compare the effectiveness of local Triamcinolone therapy for active thyroid orbitopathy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age>18 years.
- •Active thyroid orbitopathy according to clinical activity score>=3.
排除标准
- •Intraorbital or active infections.
- •Tuberculosis.
- •Other orbital disease.
- •Pregnancy.
- •Compressive optic neuropathy.
- •Systemic steroid therapy within 6 months of study start.
研究组 & 干预措施
Triamcinolone
干预措施: Triamcinolone (Drug)
结局指标
主要结局
Comparing the effectiveness of subconjunctival and peribulbar Triamcinolone injection to systemic Steroid therapy for patients with active thyroid orbitopathy .
时间窗: 6 months
Every month, each participant will undergo several tests : blood sugar, full ocular examination, color test, visual field and ultrasound test for measuring the thickness of extraocular muscles.Clinical activity score for thyroid orbitopathy will be assesed too. The results of the clinical and ultrasonogrophic findings will determine the effectiveness of the treatment. A patient with deterioration of thyroid orbitopathy during the research, will be treated by systemic Steroids in addition to the local injections.
次要结局
- To check if the level of TSH Receptor antibodies are affected by the local injection.(4 months)