Diffusion Imaging in Acute Auto-immune Encephalitis
- Conditions
- Auto-immune Encephalitis
- Registration Number
- NCT04339205
- Lead Sponsor
- Hospices Civils de Lyon
- Brief Summary
The aim of this non randomised retrospective study is to investigate the imaging (MRI) of auto-immune encephalitis at presentation, especially in diffusion-weighted sequences.
Indeed, few series describe the MRI aspect of auto-immune at their beginning. Recognize early MRI abnormalities seen in auto-immune encephalitis could help reduce the time to positive diagnosis and improve the therapeutic management.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 80
- Auto-immune encephalitis proved by biological results (blood and/or CSF sample)
- No MRI available
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method MRI characterization, especially in Diffusion-weighted magnetic resonance imaging (DWI-MRI), of auto-immune encephalitis at presentation. at following-up until 24 months The radiologist will analyze the MRI of patients with proved auto-immune encephalitis realized at presentation of the symptoms. If available, the following-up MRIs will also be analyzed.
At each assessment, four MRI sequences will be studied : diffusion, T2-weighted, susceptibility sensitive sequences, and T1 weighted after contrast enhanced with gadolinium.
The radiologist will analyse the signal abnormalities, their localisation and the trophicity of the brain.
We will then correlate the following clinical data collected for patients : age, sex, clinical presentation, clinical evolution, and tumor associated or not.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hospices Civils de Lyon
🇫🇷Pierre-Bénite, France