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A 12 Week Study in Patients With Type 2 Diabetes Mellitus (T2DM)

Phase 2
Completed
Conditions
Type 2 Diabetes Mellitus
Interventions
Drug: LCQ908A
Drug: Placebo
Registration Number
NCT00901979
Lead Sponsor
Novartis Pharmaceuticals
Brief Summary

This study will assess the effect of LCQ when added to metformin.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
693
Inclusion Criteria
  • HbA1c from 7.0-10.0%, Stable Metformin dose
Exclusion Criteria
  • CHF Class III-IV, Liver disease

Other protocol-defined inclusion/exclusion criteria may apply

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Placebometformin-
SitagliptinSitagliptin-
Sitagliptinmetformin-
LCQ908 Dose 1metformin-
LCQ908 Dose 2LCQ908A-
LCQ908 Dose 2metformin-
LCQ908 Dose 3LCQ908A-
LCQ908 Dose 4LCQ908A-
LCQ908 Dose 1LCQ908A-
LCQ908 Dose 5LCQ908A-
LCQ908 Dose 5metformin-
PlaceboPlacebo-
LCQ908 Dose 3metformin-
LCQ908 Dose 4metformin-
Primary Outcome Measures
NameTimeMethod
Effect of LCQ on measures of glucose control12 weeks
Secondary Outcome Measures
NameTimeMethod
Changes in body weight and related measures12 weeks
Insulin sensitivity12 weeks
Safety and tolerability12 weeks

Trial Locations

Locations (67)

Metabolic Research Institute, Inc.

🇺🇸

West Palm Beach, Florida, United States

John Muir Clinical Research

🇺🇸

Concord, California, United States

Dallas Diabetic and Endocrinology Research Center

🇺🇸

Dallas, Texas, United States

Radiant Research - North Dallas

🇺🇸

Dallas, Texas, United States

Credit Valley Prof Bldg

🇨🇦

Mississauga, Ontario, Canada

Southwestern Medical Clinic

🇺🇸

Bridgman, Michigan, United States

Michigan State University - Kalamazoo Ctr for Med Studies

🇺🇸

Kalamazoo, Michigan, United States

Mississippi Medical Research, LLC

🇺🇸

Picayune, Mississippi, United States

Clinique Médicale Millénia Santé

🇨🇦

Québec, Quebec, Canada

Accurate Clinical Research

🇺🇸

Houston, Texas, United States

Blalock Clinical Research

🇺🇸

Houston, Texas, United States

Texas Center for Drug Development, P.A.

🇺🇸

Houston, Texas, United States

Research Center Phase I-IV of Florida, Corp.

🇺🇸

Miami, Florida, United States

Clinical Research Advantage

🇺🇸

Mesa, Arizona, United States

Mesa Family Medical Center/Clinical Research Advantage

🇺🇸

Mesa, Arizona, United States

Apex Research of Riverside

🇺🇸

Riverside, California, United States

MacNeal Center for Clinical Research

🇺🇸

Berwyn, Illinois, United States

Rivergrove Medical Clinic

🇨🇦

Winnipeg, Manitoba, Canada

Cotton-O'Neil Clinical Research Center Topeka KS United States

🇺🇸

Topeka, Kansas, United States

Health Sciences Centre - Diabetes Research Group

🇨🇦

Winnipeg, Manitoba, Canada

Complete Family Care

🇺🇸

Northglenn, Colorado, United States

CNRI-San Diego, LLC

🇺🇸

San Diego, California, United States

California Research Foundation

🇺🇸

San Diego, California, United States

Denver VA Medical Center

🇺🇸

Denver, Colorado, United States

Woodland International Reserach Group, LLC

🇺🇸

Little Rock, Arkansas, United States

Associated Pharmaceutical Research

🇺🇸

Buena Park, California, United States

Orange County Research Center

🇺🇸

Tustin, California, United States

Samodzielny Publiczny Zaklad Opieki Zdrowotnej

🇵🇱

Olawa, Poland

Diablo Clinical

🇺🇸

Walnut Creek, California, United States

Perimeter North Medical Research

🇺🇸

Roswell, Georgia, United States

Venture Resource Group

🇺🇸

Overland Park, Kansas, United States

Graves Gilbert Clinic Bowling Green KY United States

🇺🇸

Bowling Green, Kentucky, United States

Commonwealth Biomedical Research, LLC

🇺🇸

Madisonville, Kentucky, United States

Centennial Medical Group

🇺🇸

Elkridge, Maryland, United States

International Research Center Towson MD United States

🇺🇸

Towson, Maryland, United States

Clarkston Medical Group

🇺🇸

Clarkston, Michigan, United States

Fallon Clinic Worcester MA United States

🇺🇸

Worcester, Massachusetts, United States

ClinVest Research

🇺🇸

Springfield, Missouri, United States

Montana Medical Research

🇺🇸

Missoula, Montana, United States

St. John's Clinic - Medical Research

🇺🇸

Springfield, Missouri, United States

Meera Dewan, P.C.

🇺🇸

Omaha, Nebraska, United States

Libra Clinical Research Associates

🇺🇸

Brick, New Jersey, United States

Physicians Research Center

🇺🇸

Toms River, New Jersey, United States

*Private Practice* Staten Island

🇺🇸

Staten Island, New York, United States

Southwind Medical Specialists Memphis TN United States

🇺🇸

Memphis, Tennessee, United States

Medical Frontiers LLC

🇺🇸

Carlisle, Ohio, United States

Ettrick Health Center

🇺🇸

Ettrick, Virginia, United States

McGuire Veterans Medical Center

🇺🇸

Richmond, Virginia, United States

Northwest Clinical Research

🇺🇸

Bellevue, Washington, United States

Providence Physicians Group

🇺🇸

Monroe, Washington, United States

CHUS - Hopital Fleurimont

🇨🇦

Sherbrooke, Quebec, Canada

Hopital Maisonneuve-Rosemont

🇨🇦

Montreal, Quebec, Canada

Institut de Recherches Cliniques

🇨🇦

Montreal, Quebec, Canada

Hamilton Medical Research Group

🇨🇦

Sherbrooke, Ontario, Canada

A.O.Polo Universitario Luigi Sacco

🇮🇹

Milano, Italy

Centro Studi sull'Invecchiamento CeSI-Univers.G.D'Annunzio

🇮🇹

Chieti, Italy

Azienda Ospedaliera-Ospedali Riuniti di Bergamo

🇮🇹

Bergamo, Italy

Presidio Ospedaliero di Cisanello Università degli Studi

🇮🇹

Pisa, Italy

Istituto Scientifico San Raffaele - IRCCS

🇮🇹

Milano, Italy

Ospedale S.Giovanni di Dio

🇮🇹

Olbia, Italy

Policlinica Dr. Luis Rodriguez Carrasquillo

🇵🇷

Carolina, Puerto Rico

Univ.Tor Vergata - AUSL ROMA B - Sede Territoriale

🇮🇹

Roma, Italy

Endocrine Lipid Diabetes Research Institute Ponce PR United States

🇵🇷

Ponce, Puerto Rico

Miguel Sosa-Padilla, M.D.

🇵🇷

San Juan, Puerto Rico

Endwell Family Physician

🇺🇸

Endwell, New York, United States

*Private Practice*

🇺🇸

Pasadena, California, United States

Radiant Research

🇺🇸

Greer, South Carolina, United States

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