Serpin C and Soluble Fms-like Tyrosine Kinase-1 Levels in Normotensive Pregnant Women May Predict the Development of Preeclampsia

Completed

• Conditions: Pre-Eclampsia
• Interventions: Diagnostic Test: ELISA

• Registration Number: NCT06214702
• Lead Sponsor: Benha University

Brief Summary

Evaluation of the predictability of estimated levels of Serpin C, sFlt-1 and placental growth factor (PLGF) in blood samples obtained during the 1st trimester from normotensive pregnant women for identification of women liable to develop PE during the course of pregnancy.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-07
• Primary Completion: 2023-05-12
• Study Completion: 2023-11-15
• Status Verified: 2024-01
• Study First Submitted: 2024-01-10
• Study First Submitted QC: 2024-01-18
• Last Update Submitted: 2024-01-18
• Study First Posted: 2024-01-22
• Last Update Posted: 2024-01-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

• Normotensive pregnant women had singleton fetus presenting during the 1st trimester
• free of exclusion criteria

Exclusion Criteria

• Age
• Sex
• Hypertension

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control Group	ELISA	Patients were normotensive at the 20th GW.
Study group	ELISA	Patients with diastolic blood pressure (DBP) after the 20th GW up ≥140 or 90 mmHg without proteinuria.

Primary Outcome Measures

Name	Time	Method
Role of Biomarkers in detection of GHTN	9 months	The predictability of serum biomarkers' levels estimated at enrolment for the development of GHTN.

Trial Locations

Locations (1)

Banha University; 🇪🇬 Banhā, El- Qalyobia, Egypt