A Clinical Study on Quantitative Analysis of Antibacterial Efficacy of Herbal Irrigants Against Endodontic Microflora

Phase 2/3

Completed

Conditions: Necrosis of pulp, (2) ICD-10 Condition: 8||Other Procedures,

Registration Number: CTRI/2023/09/057727

Lead Sponsor: Lovely Das

Brief Summary: The main objectives of the non-surgical endodontic treatment are the elimination of micro-organisms from the root canal space and the prevention of reinfection. Chemomechamical preparation is considered to be one of the most important steps in the management of infected root canal system which includes proper instrumentation and meticulous irrigation. Ideally, an endodontic irrigant should have antimicrobial efficacy, tissue dissolving capacity along with nontoxic and biocompatible nature. Through the years, various irrigating solutions have been used in contemporary dentistry, however none of them has all the properties needed. So, a combined use of separate irrigants is recommended to ensure the successful outcome, which makes the procedure quite lengthy. Sodium hypochlorite (NaOCl), is a reducing agent, straw colored solution used majorly as the main root canal irrigant and responsible for antimicrobial action. On the basis of published data, a wide range of percentage of sodium hypochlorite can be used from 0.5% - 5.2%. nevertheless, it has some serious complications, some of which are life-threatening. It causes chemical burn on extrusion to the periapical area during root canal treatment. In higher concentration it causes hemolysis, ulceration, inhibition of neutrophil migration, damage to fibroblast cells, and necrosis on extrusion to surrounding tissue. Herbal irrigants are comparatively newer irrigant in the field of endodontics, focus on the owning of their advantages and minimal side effects. Neem and green tea are full of different flavonoids, catechins which antimicrobial and beneficial in various ways. Therefore, the aim of this study is to evaluate and compare the antimicrobial efficacy of these two herbal irrigants with most commonly used irrigant, sodium hypochlorite.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 60

Inclusion Criteria

Pulpal necrosis tooth with Symptomatic apical periodontits or Asymptomatic apical periodontitis in Single / multirooted tooth ( in case of multirooted tooth the largest canal for posterior teeth).

Exclusion Criteria

Wide/open apex Re â€“ treatment endodontic cases Acute apical abscess Periodontal disease (presence of pocket >4 mm) Pregnant patient Medically compromised patients Calcified canal Internal resorption cases Patient who is on antibiotic medications for the last 3 months.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. To evaluate the efficacy of Neem solution against micro-organisms present in root canal.	Before & after using the designated solution
2. To evaluate the efficacy of Green tea solution against micro-organisms present in root canal.	Before & after using the designated solution

Secondary Outcome Measures

Name	Time	Method
1. To evaluate & compare the antimicrobial efficacy of Neem and Green tea solution.	2. To evaluate and compare the antimicrobial efficacy of Neem and Green tea solution with the Sodium hypochlorite.

Trial Locations

Locations (1): Guru Nanak IInstitute of Dental Sciences and Research
🇮🇳
Kolkata, WEST BENGAL, India
Guru Nanak IInstitute of Dental Sciences and Research
🇮🇳Kolkata, WEST BENGAL, India
Dr Lovely Das
Principal investigator
08274863635
drlovelydas@gmail.com