Chinese Observational Prospective Study of Aging Population With Chronic Kidney Disease(C-OPTION)
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Chronic Kidney Disease
- Sponsor
- Chinese PLA General Hospital
- Enrollment
- 3000
- Primary Endpoint
- Death
- Last Updated
- 8 years ago
Overview
Brief Summary
The study is an observational, multicenter, prospective cohort study aimed at evaluating a 5-year screening programme for chronic kidney disease(CKD) in a population of elderly patients, aged 65 years or more, in China.To analyze the etiology and composition spectrum, the incidence of complications and co-morbidities.To assess the correlation between daily living ability, mental and physical function, quality of life, nutritional status and prognosis.To develop biomarkers of renal aging.
Investigators
Chen Xiangmei
Academician of Chinese Academy of Engineering
Chinese PLA General Hospital
Eligibility Criteria
Inclusion Criteria
- •age≥65 years
- •clinical diagnosis of CKD
- •signed informed consent
Exclusion Criteria
- •subjects who have a poor compliance and cannot be scheduled for follow-up
- •subjects participating in other interventional clinical trials
- •ESRD or dialysis
- •Acute kidney injury(AKI)
- •history of solid organ or bone marrow transplantation
- •active malignancy within 24 months prior to screening or metastatic cancer
- •life expectancy less than 6 months；
- •severe cognitive impairment（NYHA III or IV）
- •HIV infection or AIDS
- •subjects cannot be able to complete the assessment including dementia or other mental disorders, limited physical activity, severe visual impairment
Outcomes
Primary Outcomes
Death
Time Frame: 5 year
Incidence of End Stage Renal Disease (ESRD)
Time Frame: 5 year
ESRD will be defined as estimated glomerular filtration rate(eGFR)\<15 mL/min/1.73 m2 or dialysis
eGFR decline≥40%
Time Frame: 5 year
Secondary Outcomes
- Heart failure(5 year)
- Acute coronary syndrome(5 year)
- Peripheral arterial disease(5 year)
- Cerebral stroke(5 year)