NCT03405545已完成不适用
High Intensity Interval Training and Skeletal Muscle Insulin Sensitivity: Unraveling Health Effects and Underlying Mechanisms
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Non-oxidative glucose disposal
研究概览
简要总结
This human intervention study will test if 12 weeks of supervised HIIT-based intervention improves skeletal muscle NOGD capacity in obese subjects.
详细描述
19 overweight-obese (BMI => 27kg/m2), sedentary females and males aged 45-75yr will be enrolled in this study.
Participants will train 3 times/week under supervision during 12 weeks. Before, after and during this 12-week training period, there will be multiple metabolic measurements.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Signed informed consent
- •Age 45 - 75 years old
- •Overweight to obese (BMI => 27kg/m2)
- •Sedentary - subjects do not perform any regular physical activity weekly(<3 times per week, <150 min/week).
排除标准
- •Unstable body weight (weight gain or loss > 3 kg in the past three months)
- •Participation in an intensive weight-loss program or in vigorous exercise program during the last year before starting the study.
- •HbA1c > 6.5% and glucose clearance rate >350 ml/kg/min (by OGTT).
- •Previously diagnosed with type 2 diabetes
- •Active cardiovascular disease. This will be determined by the questionnaires and by screening on medication.
- •Use of beta-blockers
- •Anticoagulant therapy
- •Systolic blood pressure >160 mmHg or diastolic blood pressure >100 mmHg
- •Abuse of alcohol (> 3 units (1 unit = 10 gr ethanol) per day)
- •Any contra-indication to Magnetic Resonance Imaging (MRI) scanning
- •Participation in another biomedical study within 1 month before the first study visit, which may interfere with the outcomes of the present study.
- •Use of any medication affecting the glucose homeostasis and whole body metabolism or diseases that may significantly interfere with the main aim of the study.
- •Chronic renal dysfunction (creatinine >2 increased (normal value 64-104 µmol/l)
- •Subjects who do not want to be informed about unexpected medical findings during the screening / study, or do not wish that their physician is informed, cannot participate in the study.
- •Subjects will be included only when the dependent medical doctor of this study approves participation after evaluating all data obtained during the screening.
结局指标
主要结局
Non-oxidative glucose disposal
时间窗: 9 hours
Measured during a 2-step hyperinsulinemic-euglycemic clamp combined with indirect calorimetry
次要结局
- 24 hour glycaemic profile(48 hours)
- Skeletal muscle glycogen content(1 hour)
- Skeletal muscle insulin sensitivity(9 hours)
- Skeletal muscle mitochondrial function assessed by Magnetic Resonance Spectroscopy Scan using 31P-MRS methodology, based on the phosphocreatine (PCr) recovery kinetics after exercise.(1 hour)
- Ectopic Fat accumulation in the liver assessed by magnetic resonance spectroscopy.(1 hour)
- Maximal Acetylcarnitine formation in the upper-leg at rest and after exercise assessed by Magnetic Resonance Spectroscopy Scan(1 hour)
- Metabolic Flexibility during exercise assessed by indirect calorimetry.(30 minutes)
研究者
研究点 (2)
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