A randomized comparative study to compare the effect of intraperitoneal dexmedetomidine and intravenous dexmedetomidine on the post operative recovery and inflammatory response in patients undergoing laparoscopic cholecystectomy
Phase 2
- Conditions
- Health Condition 1: K802- Calculus of gallbladder without cholecystitisHealth Condition 2: O- Medical and Surgical
- Registration Number
- CTRI/2024/05/067316
- Lead Sponsor
- niversity College of Medical Sciences and Guru Teg Bahadur Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Consenting male or female patients aged 18-60 years scheduled for elective
Laparoscopic cholecystectomy under general anaesthesia.
2. Belonging to ASA grade I or II
Exclusion Criteria
1. Patients with abnormalities like heart block, conduction defect in pre-operative ECG
2. Patients with known allergies to the study drugs
3. Obese patients (BMI = 30)
4. Patients in whom subhepatic drain is inserted after gall bladder removal
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of time for extubation in the two groups.Timepoint: Time taken from administration of reversal drug to removal of endotracheal tube
- Secondary Outcome Measures
Name Time Method <br/ ><br>To compare between the two groups various inflammatory markers such as:- <br/ ><br>i) IL-6 <br/ ><br>ii) CRP <br/ ><br> iii) S. Cortisol <br/ ><br> iv) S. Albumin <br/ ><br> v) Blood Glucose <br/ ><br>Timepoint: pre-operative and six hours post induction;To compare between the two groups – <br/ ><br>1.Time to discharge from PACU using Modified Aldrete score. 2. Hemodynamic parameters at the time of extubation <br/ ><br>3 Post-operative pain using Numeric Rating Scale (NRS) <br/ ><br>Timepoint: post operative;To compare between the two groups – <br/ ><br>Amount of rescue analgesia required in 24 hoursTimepoint: 24 hours post operative