Pilot Study of Wearable Artificial Kidney
Phase 1
Completed
- Conditions
- Renal Failure
- Registration Number
- NCT00454974
- Lead Sponsor
- Royal Free Hampstead NHS Trust
- Brief Summary
This is a pilot study of a wearable type of kidney dialysis machine to treat patients with chronic kidney disease.
- Detailed Description
This is a pilot study to evaluate the clearances, tolerability and safety of a wearable artificial kidney device for treating patients with chronic kidney failure.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 8
Inclusion Criteria
- End stage renal failure
- Regular haemodialysis
- Cardiovascular stability
- Stable vascular access
Exclusion Criteria
- Allergy to heparin or ethylene oxide
- Recent cardiovascular or neurological event
- Unable to provide informed consent
- Age < 18
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method urea, potassium, phosphate and B2M clearances safety - cardiovascular,no hemolysis, bleeding, infection no ammonia generation from sorbents, control of acid base balance
- Secondary Outcome Measures
Name Time Method fluid removal patient satisfaction questionnaire affect of treatment of cytokines
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie the wearable artificial kidney's clearance of toxins in endstage renal failure?
How does the wearable artificial kidney compare to conventional hemodialysis in terms of efficacy and patient outcomes for chronic kidney disease?
Which biomarkers are associated with improved tolerability and safety outcomes in wearable artificial kidney trials for renal failure patients?
What are the potential adverse events and management strategies for the wearable artificial kidney in treating endstage renal failure?
Are there any related compounds or combination therapies being developed alongside wearable artificial kidney technology for chronic kidney disease?
Trial Locations
- Locations (1)
UCL Center for Nephrology
🇬🇧London, United Kingdom
UCL Center for Nephrology🇬🇧London, United Kingdom