Protective mechanical ventilation during open surgery on the abdomen with general anaesthesia
- Conditions
- Ventilator acquired lung injury (VILI)Injury, Occupational Diseases, PoisoningLung injury
- Registration Number
- ISRCTN70332574
- Lead Sponsor
- Academic Medical Centre (AMC) (Netherlands)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 900
1. Planned elective abdominal surgery
2. General anaesthesia with intravenous medication
3. High or intermediate risk for post-operative pulmonary complications
4. Aged greater than or equal to 18 years, either sex
1. Aged less than 18 years
2. Body mass index greater than 40 kg/m^2
3. Laparoscopic surgery
4. Previous lung surgery (any)
5. Persistent haemodynamic instability, intractable shock (considered haemodynamic unsuitable for the study by the patient's managing physician)
6. History of previous severe chronic obstructive pulmonary disease (COPD) (non-invasive ventilation and/or oxygen therapy at home, repeated systemic corticosteroid therapy for acute exacerbations of COPD)
7. Recent immunosuppressive medication (patients receiving chemotherapy or radiation therapy within the last 2 months)
8. Severe cardiac disease (New York Heart Association class III or IV, or acute coronary syndrome, or persistent ventricular tachyarrhythmia's)
9. Mechanical ventilation greater than than 30 minutes (e.g., in cases of general anaesthesia because of surgery) within last 30 days
10. Pregnancy (excluded by laboratory analysis)
11. Acute lung injury or acute respiratory distress syndrome expected to require prolonged post-operative mechanical ventilation
12. Neuromuscular disease (any)
13. Consented for another interventional study or refusal to participate in the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method