Protective mechanical ventilation during surgery on the abdomen with general anesthesia.
Completed
- Conditions
- Post-operative respiratory failure
- Registration Number
- NL-OMON23359
- Brief Summary
Hemmes et al, Trials 2011, 12:111
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 900
Inclusion Criteria
1. Planned elective abdominal surgery;
2. General anesthesia with intravenous medication;
Exclusion Criteria
1. Age < 18 years;
2. Body mass index > 40 kg/m2;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postoperative pulmonary complications:<br /><br>1. Mild or severe respiratory failure;<br /><br>2. ALI/ARDS;<br /><br>3. Suspected pulmonary infection;<br /><br>4. Pulmonary infiltrate on chest X-ray;<br /><br>5. Atelectasis;<br /><br>6. Pneumothorax;<br /><br>7. Bronchospasm;<br /><br>8. Aspiration pneumonitis;<br /><br>9. Cardiopulmonary edema.
- Secondary Outcome Measures
Name Time Method 1. Intra–operative complications (desaturation, barotrauma, hypotension during recruitment, need for vasopressors);<br /><br>2. Need for ICU admission (if not as part of routine) or ICU readmission;<br /><br>3. Hospital–free days at day 90;<br /><br>4. Post–operative non–pulmonary organ function;<br /><br>5. Post–operative wound healing;<br /><br>6. Systemic levels of markers of pulmonary inflammation, acute lung injury and markers of distal organ injury.