Impact of Variable Types of Preconditioning Upon the Inotrope Score in Adult Patients, Undergoing Cardiac Surgery

Not Applicable

Completed

• Conditions: Myocardial Ischemia
• Interventions: Drug: A pharmacologic cardiac preconditioning (Sevoflurane); Procedure: B ischeamic preconditioning

• Registration Number: NCT02715869
• Lead Sponsor: Assiut University

Brief Summary

Preconditioning (PC) of the heart occurs when brief exposure to a stimulus protects the heart from subsequent ischemia. PC stimulus may be (ischemic ; pharmacologic or Physical).

Detailed Description

Preconditioning (PC) of the heart occurs when brief exposure to a stimulus protects the heart from subsequent ischemia. PC stimulus may be ( ischemic ; pharmacologic or Physical)

Pharmacological PC may be induced by variable agents e.g. (Sevoflurane ;isoflorane, opioids etc)

Ischemic PC includes local; remote and the idea is temporary interruption of blood supply to the organ so that liberation of protective mediators occurs. The liberated mediators have favorable effects not only upon the myocardium, but it extend to protect other organs against inflammatory activation; ischemia reperfusion injury

Inotropic score (IS) is already an evident predictor of postoperative cardiac morbidity and mortality

Aim of the work:

Is to validate the impact of Sevoflurane versus ischemic \& Sevoflurane PC upon postoperative inotropic score in adult patient undergoing open heart surgery

Study Timeline

• Study Start: 2016-03
• Study First Submitted: 2016-03-17
• Study First Submitted QC: 2016-03-21
• Study First Posted: 2016-03-22
• Primary Completion: 2017-03
• Study Completion: 2017-06
• Status Verified: 2017-12
• Last Update Submitted: 2017-12-09
• Last Update Posted: 2017-12-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• 18-60 years old
• American Society of Anesthesiologists physical status II and III
• Patients scheduled for open heart surgery

Exclusion Criteria

• Emergency surgery
• Clinically significant kidney or liver disease
• Patients allergic to local anesthetic
• Patients with prolonged cardiopulmonary bypass time (>120 min)
• Patients required intra-aortic balloon pump
• Postoperative hemodynamic instability (including the occurrence of serious arrhythmia) or bleeding that required surgical re-exploration

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
A pharmacologic cardiac preconditioning	A pharmacologic cardiac preconditioning (Sevoflurane)	Sevoflurane as a pharmacologic preconditioner for the heart
B ischeamic preconditioning	B ischeamic preconditioning	ischemic preconditioning by inflation the cuff of blood pressure

Primary Outcome Measures

Name	Time	Method
Highest inotropic score	first 24 hour

Trial Locations

Locations (1)

Emad Zarief Kamel Said; 🇪🇬 Assiut, Egypt