The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury

Phase 4

Completed

• Conditions: Total Knee Arthroplasty; Tourniquet-Induced Ischemia-Reperfusion Injury
• Interventions: Drug: Placebo; Drug: Propofol

• Registration Number: NCT01638624
• Lead Sponsor: Diskapi Teaching and Research Hospital

Brief Summary

The release of tourniquet produces reactive oxygen species which can cause injury. Propofol is chemically similar to phenol-based free radical scavengers.

Plasma total antioxidant capacity is a well-established marker of the overall protective effect of antioxidants in body fluids.The aim of the study is to investigate the effects of propofol on ischemia-reperfusion injury in total knee arthroplasty (TKA).

Detailed Description

Not available

Study Timeline

• Study Start: 2012-06
• Status Verified: 2012-07
• Study First Submitted: 2012-07-03
• Study First Submitted QC: 2012-07-11
• Study First Posted: 2012-07-12
• Primary Completion: 2012-10
• Study Completion: 2012-11
• Last Update Submitted: 2016-06-10
• Last Update Posted: 2016-06-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• ASA I-II physical status
• Unilateral total knee arthroplasty
• Age 18 years to 80 years

Exclusion Criteria

• Severe central nervous system disorders
• Severe cardiopulmonary,renal,metabolic, or hepatic disease,
• Blood volume deficits,
• Coagulopathy,
• Allergy to local anesthetics,
• Peripheral neuropathies,
• Body mass index > 35,
• History of antioxidant drug use

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	Placebo	Placebo group: Under spinal anesthesia, a continuous intravenous infusion of volume-equivalent placebo will use during the operation
Propofol	Propofol	Propofol infusion group: Under spinal anesthesia, a continuous intravenous infusion (2mg/kg/h) of propofol will be use during the operation

Primary Outcome Measures

Name	Time	Method
The perioperative alternation of the venous blood total antioxidant capacity levels of the arms	T1,T2,T3	T1 : Before the spinal anesthesia performed T2 : At 30th min of tourniquet inflation T3 : At 2nd hours of tourniquet deflation

Trial Locations

Locations (1)

Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology and Biochemistry Clinics; 🇹🇷 Ankara, Turkey