CMR characterization of ablation lesions following pulmonary vein isolation.

Recruiting

• Conditions: Atrial fibrillation; 10007521

• Registration Number: NL-OMON52010
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Adult patients (age >=18 years old)
Paroxysmal or persistent atrial fibrillation meeting guideline criteria.
Anticipated pulonary vain isololation using index guided radiofrequency
ablation techniques.
Availability of contrast-enhanced cardiac MRI within 3 months before
anticipated pulmonary vein isolation.

Exclusion Criteria

History of catheter ablation
History of cardiac surgery
History of chest radiation therapy
Known (or suspected) allergic reaction to gadolinium
Estimated glomerular filtration rate (eGFR) <45 ml/min/kg
Contraindications for CMR
Inability to schedule CMR <72h after PVI
Long-term use of anti-inflammatory medication, except for the use of
nonsteroidal anti-inflammatory drugs
Autoimmune disease or chronic inflammatory illness.
Pregnancy of breast feeding

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The relation between ablation lesion characteristics in the early phase after<br /><br>pulmonary vein isolation and (1) ablation scar at 3 months follow-up, and (2)<br /><br>atrial fibrillation-free survival at 1 year.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>N.a.</p><br>