The role of the antioxidants ascorbic acid and n-acetylcysteine in the attenuation of ischaemia reperfusion injury in a human model

• Conditions: Ischaemia reperfusion injury; MedDRA version: 9.1Level: LLTClassification code 10063837Term: Reperfusion injury; MedDRA version: 9.1Level: PTClassification code 10063837Term: Reperfusion injury

• Registration Number: EUCTR2008-004613-10-IE
• Lead Sponsor: niversity College Hospital Galway

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2008-07-14
• Last Update Posted: 19 March 2012

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Patients undergoing elective knee surgery
Age range 18-60
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

Smokers
Patients on vitamin supplements
Patients on anti-inflammatory medications
Patients with inflammatory medical conditions (eg Crohn's disease, UC, SLE, RA)
Patients with diabetes
Patients with a history of renal calculi
Pregnant women

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified