Bemarituzumab or Placebo Plus Chemotherapy in Gastric Cancers With Fibroblast Growth Factor Receptor 2b (FGFR2b) Overexpression
- Conditions
- Gastric CancerGastroesophageal Junction Adenocarcinoma
- Interventions
- Registration Number
- NCT05052801
- Lead Sponsor
- Amgen
- Brief Summary
The main objective of this study is to compare efficacy of bemarituzumab combined with oxaliplatin, leucovorin, and 5-fluorouracil (5-FU) (mFOLFOX6) to placebo plus mFOLFOX6 as assessed by overall survival (OS) in participants with FGFR2b ≥10% 2+/3+ tumor cell staining (FGFR2b ≥10% 2+/3+TC)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 547
-
Adults with histologically documented unresectable, locally advanced or metastatic gastric or gastroesophageal junction cancer not amenable to curative therapy
-
Fibroblast growth factor receptor 2b (FGFR2b) ≥10% 2+/3+ tumor cell staining as determined by centrally performed immunohistochemistry (IHC) testing, based on tumor sample either archival (obtained within 6 months/180 days prior to signing pre-screening informed consent) or a fresh biopsy
-
Eastern Cooperative Oncology Group (ECOG) less than or equal to 1
-
Measurable disease or non-measurable, but evaluable disease, according to Response Evaluation Criteria in Solid Tumors (RECIST) V 1.1
-
Participant has no contraindications to mFOLFOX6 chemotherapy
-
Adequate organ and bone marrow function:
- absolute neutrophil count greater than or equal to 1.5 times 10^9/L
- platelet count greater than or equal to 100 times 10^9/L
- hemoglobin ≥ 9 g/dL without red blood cell (RBC) transfusion within 7 days prior to the first dose of study treatment
- aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than 3 times the upper limit of normal (ULN) (or less than 5 times ULN if liver involvement). Total bilirubin less than 1.5 times ULN (or less than 2 times ULN if liver involvement); with the exception of participants with Gilbert's disease)
- calculated or measured creatinine clearance (CrCl) of ≥ 30 mL/minute calculated using the formula of Cockcroft and Gault ([140 - Age]) × Mass [kg]/[72 × Creatinine mg/dL]) (x 0.85 if female)
- international normalized ratio (INR) or prothrombin time (PT) less than 1.5 times ULN except for participants receiving anticoagulation, who must be on a stable dose of anticoagulant therapy for 6 weeks prior to enrollment
- Prior treatment for metastatic or unresectable disease (Note: prior adjuvant, neo-adjuvant, and peri-operative therapy is allowed if completed more than 6 months prior to first dose of study treatment)
- Prior treatment with any selective inhibitor of fibroblast growth factor - fibroblast growth factor receptor (FGF-FGFR) pathway
- Known human epidermal growth factor receptor 2 (HER2) positive
- Untreated or symptomatic central nervous system (CNS) disease or brain metastases
- Peripheral sensory neuropathy greater than or equal to Grade 2
- Clinically significant cardiac disease
- Other malignancy within the last 2 years (exceptions for definitively treated disease)
- Chronic or systemic ophthalmological disorders
- Major surgery or other investigational study within 28 days prior to first dose of study treatment
- Palliative radiotherapy within 14 days prior to the first dose of study treatment
- Evidence of or recent history (within 6 months) of corneal defects, corneal ulcerations, keratitis, or keratoconus, history of corneal transplant, or other known abnormalities of the cornea that may pose an increased risk of developing a corneal ulcer.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Bemarituzumab with mFOLFOX6 Bemarituzumab - Bemarituzumab with mFOLFOX6 mFOLFOX6 - Placebo with mFOLFOX6 mFOLFOX6 - Placebo with mFOLFOX6 Placebo -
- Primary Outcome Measures
Name Time Method Overall Survival Up to approximately 3.5 years Overall survival in FGFR2b ≥ 10% 2+/3+ tumor cell staining participants
- Secondary Outcome Measures
Name Time Method Progression-free Survival (PFS) Up to approximately 3.5 years PFS in all randomized participants
Objective Response Rate (ORR) Up to approximately 3.5 years ORR in all randomized participants
Mean Subjective Score in European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (QLQ-C30) Up to approximately 3.5 years Measured in FGFR2b ≥ 10% 2+/3+ tumor cell staining participants
Change from Baseline Score in European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (QLQ-C30) Baseline up to approximately 3.5 years Measured in FGFR2b ≥ 10% 2+/3+ tumor cell staining participants
Stomach Cancer Related Symptom Mean Subjective Score as Measured by European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Stomach (EORTC-QLQ-STO22) Up to approximately 3.5 years Measured in FGFR2b ≥ 10% 2+/3+ tumor cell staining participants
Mean Subjective Score in Visual Analogue Scale (VAS) as Measured by the EuroQol 5-dimensional 5-levels (EQ-5D-5L) Up to approximately 3.5 years Measured in FGFR2b ≥ 10% 2+/3+ tumor cell staining participants
Maximum Observed Concentration (Cmax) of Bemarituzumab in Combination with mFOLFOX6 in Plasma Day 1 up to approximately 3.5 years Observed Concentration at the End of a Dose Interval (Ctrough) of Bemarituzumab in Combination with mFOLFOX6 in Plasma Day 1 up to approximately 3.5 years Disease Control Rate Up to approximately 3.5 years Disease Control Rate in FGFR2b ≥ 10% 2+/3+ tumor cell staining participants
Number of Participants who Experience a Treatment-emergent Adverse Event (TEAE) Up to approximately 3.5 years Any clinically significant changes in vital signs, visual acuity, and clinical laboratory tests after first dose will be recorded as TEAEs.
Overall Survival Up to approximately 3.5 years Overall survival in all randomized participants
Duration of Response (DOR) Up to approximately 3.5 years DOR in FGFR2b ≥ 10% 2+/3+ tumor cell staining participants
Change from Baseline in Stomach Cancer Related Symptom Score as Measured by European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Stomach (EORTC-QLQ-STO22) Baseline up to approximately 3.5 years Measured in FGFR2b ≥ 10% 2+/3+ tumor cell staining participants
Time to Deterioration in Physical Function Score as Measured by a Subscale of European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (QLQ-C30) Day 1 up to approximately 3.5 years Measured in FGFR2b ≥ 10% 2+/3+ tumor cell staining participants
Change from Baseline of Visual Analogue Scale (VAS) as Measured by the EuroQol 5-dimensional 5-levels (EQ-5D-5L) Baseline up to approximately 3.5 years Measured in FGFR2b ≥ 10% 2+/3+ tumor cell staining participants
Time to Deterioration in Stomach Cancer Related Symptom Score as Measured by European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Stomach (EORTC-QLQ-STO22) Up to approximately 3.5 years Measured in FGFR2b ≥ 10% 2+/3+ tumor cell staining participants
Time to Deterioration in European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (QLQ-C30) Score Up to approximately 3.5 years Measured in FGFR2b ≥ 10% 2+/3+ tumor cell staining participants
Time to Deterioration in Visual Analogue Scale (VAS) as Measured by the EuroQol 5-dimensional 5-levels (EQ-5D-5L) Score Up to approximately 3.5 years Measured in FGFR2b ≥ 10% 2+/3+ tumor cell staining participants
Number of Participants with an Anti-bemarituzumab Antibody Formation Day 1 up to approximately 3.5 years
Trial Locations
- Locations (299)
251 General Airforce Hospital
🇬🇷Athens, Greece
General Hospital of Athens Laiko
🇬🇷Athens, Greece
Evgenidio Hospital I Agia Trias
🇬🇷Athens, Greece
Metropolitan Hospital
🇬🇷Athens, Greece
Szpitale Pomorskie Spzoo
🇵🇱Gdynia, Poland
Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji
🇵🇱Olsztyn, Poland
Szpital Wojewodzki imienia Mikolaja Kopernika w Koszalinie
🇵🇱Koszalin, Poland
Wojewodzki Szpital im Sw Ojca Pio w Przemyslu
🇵🇱Przemysl, Poland
Hospital Provincial del Centenario
🇦🇷Rosario, Santa Fe, Argentina
Lietuvos sveikatos mokslu universiteto ligonine viesoji istaiga Kauno klinikos
🇱🇹Kaunas, Lithuania
Investigación Biomédica para el Desarrollo de Fármacos
🇲🇽Aguascalientes, Mexico
Institutul Regional de Oncologie Iasi
🇷🇴Iasi, Romania
National Cancer Centre Singapore
🇸🇬Singapore, Singapore
Unidade Local de Saude de Entre Douro e Vouga, EPE - Hospital de Sao Sebastiao
🇵🇹Santa Maria da Feira, Portugal
Ovidius Clinical Hospital
🇷🇴Ovidiu, Romania
Sarawak General Hospital
🇲🇾Kuching, Sarawak, Malaysia
Hospital Civil de Guadalajara Fray Antonio Alcalde
🇲🇽Guadalajara, Jalisco, Mexico
Rajavithi Hospital
🇹🇭Bangkok, Thailand
Tri-Service General Hospital
🇨🇳Taipei, Taiwan
University Malaya Medical Centre
🇲🇾Kuala Lumpur, Wilayah Persekutuan, Malaysia
China Medical University Hospital
🇨🇳Taichung, Taiwan
King Chulalongkorn Memorial Hospital
🇹🇭Bangkok, Thailand
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung, Taiwan
Kaohsiung Chang Gung Memorial Hospital
🇨🇳Kaohsiung, Taiwan
Ramathibodi Hospital
🇹🇭Bangkok, Thailand
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
Alaska Oncology and Hematology
🇺🇸Anchorage, Alaska, United States
The Ottawa Hospital Cancer Centre
🇨🇦Ottawa, Ontario, Canada
University Multiprofile Hospital for Active Treatment Dr Georgi Stranski EAD
🇧🇬Pleven, Bulgaria
Centro de Pesquisa e Ensino em Oncologia de Santa Catarina
🇧🇷Florianopolis, Santa Catarina, Brazil
Instituto de Ensino e Pesquisa Sao Lucas Iep Sao Lucas
🇧🇷Santo Andre, São Paulo, Brazil
Centro de Estudios Clinicos SAGA Spa
🇨🇱Santiago, Chile
Multiprofile Hospital for Active Treatment Park Hospital EOOD
🇧🇬Branipole Village, Bulgaria
Mayo Clinic Florida
🇺🇸Jacksonville, Florida, United States
Healthier Hematology and Oncology Excelsior Integrated Medical Group
🇺🇸Brooklyn, New York, United States
Cross Cancer Institute
🇨🇦Edmonton, Alberta, Canada
Oncosite Centro de Pesquisa Clinica Em Oncologia Ltda
🇧🇷Ijui, Rio Grande Do Sul, Brazil
Universitair Ziekenhuis Gent
🇧🇪Gent, Belgium
Clinica CIDO
🇨🇱Temuco, Cautín, Chile
Hospital Privado Universitario de Cordoba
🇦🇷Cordoba, Córdoba, Argentina
White Plains Hospital Center for Cancer Care
🇺🇸White Plains, New York, United States
Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Centro de Estudios Clinicos e Investigaciones Medicas CeCim
🇨🇱Santiago, Chile
Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD
🇧🇬Sofia, Bulgaria
Instituto Alexander Fleming
🇦🇷Caba, Buenos Aires, Argentina
Hospital Nove de Julho - dasa
🇧🇷São Paulo, Brazil
Levine Cancer Institute University
🇺🇸Charlotte, North Carolina, United States
The Oncology Institute Clinical Research
🇺🇸Cerritos, California, United States
Avera Cancer Institute
🇺🇸Sioux Falls, South Dakota, United States
Universitair Ziekenhuis Antwerpen
🇧🇪Edegem, Belgium
Medical Oncology Associates, PS
🇺🇸Spokane, Washington, United States
Centro de Oncologia Mackenzie
🇧🇷Curitiba, Paraná, Brazil
Hospital Britanico de Buenos Aires
🇦🇷Buenos Aires, Argentina
Sociedad de Beneficencia Hospital Italiano
🇦🇷Cordoba, Córdoba, Argentina
University Multiprofile Hospital for Active Treatment Pulmed OOD
🇧🇬Plovdiv, Bulgaria
North Estonia Medical Centre Foundation
🇪🇪Tallinn, Estonia
Institucion Prestadora de Servicios de Salud Sociedad Médica Rionegro SA Somer SA
🇨🇴Rionegro, Antioquia, Colombia
Fujian Medical University Union Hospital
🇨🇳Fuzhou, Fujian, China
Fakultni Thomayerova nemocnice
🇨🇿Praha 4, Czechia
Instituto Cancerologico de Narino Ltda
🇨🇴Pasto, Colombia
Linfen Central Hospital
🇨🇳Linfen, Shanxi, China
Centre Hospitalier Universitaire Amiens Picardie - Hopital Sud
🇫🇷Amiens Cedex 1, France
Hôpital Européen Georges Pompidou
🇫🇷Paris, France
Institut Mutualiste Montsouris
🇫🇷Paris Cedex 14, France
Sainte Catherine - Institut du Cancer d Avignon
🇫🇷Avignon cedex 9, France
Centre Hospitalier Universitaire de Reims - Hôpital Robert Debré
🇫🇷Reims Cedex, France
St James Hospital
🇮🇪Dublin, Ireland
Agios Savvas Anticancer Hospital
🇬🇷Athens, Greece
Azienda Ospedaliera di Rilievo Nazionale e Alta Specializzazione Garibaldi Nesima
🇮🇹Catania, Italy
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
🇮🇹Milano, Italy
Azienda Unita Saniataria Locale IRCCS di Reggio Emilia
🇮🇹Reggio Emilia, Italy
Institut de cancerologie Strasbourg Europe
🇫🇷Strasbourg cedex, France
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
University Hospital of Patras
🇬🇷Patra, Greece
Bioclinic of Thessaloniki
🇬🇷Thessaloniki, Greece
Assuta Medical Center
🇮🇱Jerusalem, Israel
Borsod-Abauj-Zemplen Varmegyei Kozponti Korhaz es Egyetemi Oktatokorhaz
🇭🇺Miskolc, Hungary
Sociedad de Oncologia y Hematologia del Cesar
🇨🇴Valledupar, Cesar, Colombia
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz
🇭🇺Nyiregyhaza, Hungary
Centre Hospitalier Régional Universitaire de Besançon, Hôpital Jean Minjoz
🇫🇷Besançon, France
Tolna Varmegyei Balassa Janos Korhaz
🇭🇺Szekszard, Hungary
Vseobecna fakultni nemocnice v Praze
🇨🇿Praha 2, Czechia
Centre Hospitalier Universitaire de Brest - Cavale Blanche
🇫🇷Brest Cedex, France
IRCCS Istituto Clinico Humanitas
🇮🇹Rozzano MI, Italy
Nagoya University Hospital
🇯🇵Nagoya-shi, Aichi, Japan
Hadassah Ein-Kerem Medical Center
🇮🇱Jerusalem, Israel
Meir Medical Center
🇮🇱Kfar Saba, Israel
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Dong-A University Hospital
🇰🇷Busan, Korea, Republic of
Masarykuv onkologicky ustav
🇨🇿Brno, Czechia
St Vincents University Hospital
🇮🇪Dublin 4, Ireland
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of
Azienda Ospedaliero Universitaria di Cagliari Policlinico Duilio Casula
🇮🇹Monserrato CA, Italy
Azienda Ospedaliera Ordine Mauriziano di Torino
🇮🇹Torino, Italy
Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center
🇯🇵Yokohama-shi, Kanagawa, Japan
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktatokorhaz
🇭🇺Gyor, Hungary
Centre Hospitalier Universitaire Nord de Saint Etienne - Hôpital Nord
🇫🇷Saint Priest en Jarez, France
National Hospital Organization Kyushu Cancer Center
🇯🇵Fukuoka-shi, Fukuoka, Japan
University Hospital of Larissa
🇬🇷Larissa, Greece
Istituto Ospedaliero Fondazione Poliambulanza
🇮🇹Brescia, Italy
Chiba Cancer Center
🇯🇵Chiba-shi, Chiba, Japan
Niigata Cancer Center Hospital
🇯🇵Niigata-shi, Niigata, Japan
Kangbuk Samsung Hospital
🇰🇷Seoul, Korea, Republic of
Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaz
🇭🇺Gyula, Hungary
The Catholic University of Korea Incheon St Marys Hospital
🇰🇷Incheon, Korea, Republic of
Chungnam National University Hospital
🇰🇷Daejeon, Korea, Republic of
Keio University Hospital
🇯🇵Shinjuku-ku, Tokyo, Japan
Aichi Cancer Center
🇯🇵Nagoya-shi, Aichi, Japan
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
The Cancer Institute Hospital of Japanese Foundation for Cancer Research
🇯🇵Koto-ku, Tokyo, Japan
Pauls Stradins Clinical University Hospital
🇱🇻Riga, Latvia
Trials In Medicine SC
🇲🇽Mexico, Mexico
National Cancer Center
🇰🇷Goyang-si Gyeonggi-do, Korea, Republic of
Kyungpook National University Chilgok Hospital
🇰🇷Daegu, Korea, Republic of
Centro de Investigacion Clinica Trujillo Eirl
🇵🇪Trujillo, La Libertad, Peru
Centro Medico Monte Carmelo
🇵🇪Arequipa, Peru
Unidade Local de Saude de Santo Antonio, EPE - Hospital de Santo Antonio
🇵🇹Porto, Portugal
Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE
🇵🇹Porto, Portugal
SC Medisprof SRL
🇷🇴Cluj-Napoca, Romania
SPZOZ Opolskie Centrum Onkologii imienia prof Tadeusza Koszarowskiego w Opolu
🇵🇱Opole, Poland
Investigacion Biomedica para el Desarrollo de Farmacos SA de CV
🇲🇽Zapopan, Jalisco, Mexico
Vilnius University Hospital Santaros Clinic Public Institution
🇱🇹Vilnius, Lithuania
Hospital Kuala Lumpur
🇲🇾Kuala Lumpur, Wilayah Persekutuan, Malaysia
Centro Oncologico Internacional
🇲🇽Tijuana, Baja California Norte, Mexico
Centrum Onkologii im prof Franciszka Lukaszczyka
🇵🇱Bydgoszcz, Poland
Karolinska Universitetssjukhuset Huddinge
🇸🇪Stockholm, Sweden
Norrlands Universitetssjukhus
🇸🇪Umea, Sweden
The Oncology Centre
🇿🇦Durban, South Africa
Instituto Peruano de Oncologia y Radioterapia
🇵🇪San Isidro, Lima, Peru
Oncosalud
🇵🇪Lima, Peru
Unidade Local de Saude do Alto Ave, EPE
🇵🇹Guimaraes, Portugal
Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria
🇵🇹Lisboa, Portugal
Spitalul Judetean de Urgenta Dr Constantin Opris Baia Mare
🇷🇴Baia Mare, Romania
Oslo University Hospital
🇳🇴Oslo, Norway
Unidade Local de Saude de Coimbra, EPE
🇵🇹Coimbra, Portugal
Unidade Local de Saude de Sao Joao, EPE - Hospital de Sao Joao
🇵🇹Porto, Portugal
Institutul Clinic Fundeni
🇷🇴Bucharest, Romania
Institutul Oncologic Prof Dr Alexandru Trestioreanu Bucuresti
🇷🇴Bucuresti, Romania
Hacettepe Universitesi Tip Fakultesi Hastanesi
🇹🇷Ankara, Turkey
Siriraj Hospital
🇹🇭Bangkok, Thailand
Baskent Universitesi Adana Doktor Turgut Noyan Uygulama ve Arastirma Merkezi
🇹🇷Adana, Turkey
Rigshospitalet
🇩🇰Copenhagen, Denmark
The First Affiliated Hospital of Anhui Medical University
🇨🇳Hefei, Anhui, China
Anhui Provincial Cancer Hospital
🇨🇳Hefei, Anhui, China
Cancer Hospital of Chinese Academy of Medical Sciences
🇨🇳Beijing, Beijing, China
Peking Union Medical College Hospital
🇨🇳Beijing, Beijing, China
Lanzhou University Second Hospital
🇨🇳Lanzhou, Gansu, China
Gansu Wuwei Tumour Hospital
🇨🇳Wuwei, Gansu, China
Cancer Hospital of Shantou University Medical College
🇨🇳Shantou, Guangdong, China
The First Affiliated Hospital of Hainan Medical University
🇨🇳Haikou, Hainan, China
Fourth Hospital of Hebei Medical University
🇨🇳Shijiazhuang, Hebei, China
Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of ScienceandTechnology
🇨🇳Wuhan, Hebei, China
Harbin Medical University Cancer Hospital
🇨🇳Harbin, Heilongjiang, China
Anyang Cancer Hospital
🇨🇳Anyang, Henan, China
The First Affiliated Hospital of Henan University of science and Technology
🇨🇳Luoyang, Henan, China
The First Affiliated Hospital of Zhengzhou University
🇨🇳Zhengzhou, Henan, China
The First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
Henan Cancer Hospital
🇨🇳Zhengzhou, Henan, China
Taihe Hospital Affiliated Hospital of Hubei University of Medicine
🇨🇳Shiyan, Hubei, China
Hubei Cancer Hospital
🇨🇳Wuhan City, Hubei, China
The First Hospital of China Medical University
🇨🇳Shenyang, Liaoning, China
Zhongshan Hospital Fudan University
🇨🇳Shanghai, Shanghai, China
Xiangya Hospital of Central South University
🇨🇳Changsha, Hunan, China
Affiliated Hospital of Jiangnan University
🇨🇳Wuxi, Jiangsu, China
China-Japan Union Hospital of Jilin University
🇨🇳Changchun, Jilin, China
Hunan Cancer Hospital
🇨🇳Changsha, Hunan, China
The Second Affiliated Hospital of Soochow University
🇨🇳Suzhou, Jiangsu, China
The Affiliated Hospital of Xuzhou Medical University
🇨🇳Xuzhou, Jiangsu, China
Nanjing First Hospital
🇨🇳Nanjing, Jiangsu, China
The First Hospital of Jilin University
🇨🇳Changchun, Jilin, China
The First Affiliated Hospital of Jinzhou Medical University
🇨🇳Jinzhou, Liaoning, China
The First Affiliated Hospital of Xi an Jiaotong University
🇨🇳XI An, Shaanxi, China
Jinan Central Hospital
🇨🇳Jinan, Shandong, China
The Affiliated Hospital of Qingdao University
🇨🇳Qingdao, Shandong, China
Fudan University Shanghai Cancer Center
🇨🇳Shanghai, Shanghai, China
Liaoning Cancer Hospital
🇨🇳Shenyang, Liaoning, China
The Affiliated Cancer Hospital of Shandong First Medical University
🇨🇳Jinan, Shandong, China
Beijing Cancer Hospital
🇨🇳Beijing, China
Taizhou Hospital of Zhejiang Province
🇨🇳Linhai, Zhejiang, China
The First Affiliate Hospital of Ningbo University
🇨🇳Ningbo, Zhejiang, China
Peoples Hospital of Quzhou
🇨🇳Quzhou, Zhejiang, China
Tianjin Medical University Cancer institute and hospital
🇨🇳Tianjin, China
Lishui Municipal central Hospital
🇨🇳Lishui, Zhejiang, China
Changzhi Peoples Hospital
🇨🇳Changzhi, Shanxi, China
Shanxi Province Cancer Hospital
🇨🇳Taiyuan, Shanxi, China
Sichuan Cancer Hospital
🇨🇳Chengdu, Sichuan, China
Azienda Ospedaliera Cardinale Giovanni Panico
🇮🇹Tricase, Italy
Azienda Sanitaria Universitaria Friuli Centrale Presidio Ospedaliero Santa Maria della Misericordia
🇮🇹Udine, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
🇮🇹Roma, Italy
Instituto Brasileiro de Controle do Cancer Ibcc
🇧🇷São Paulo, Brazil
Centre Hospitalier Universitaire de Clermont Ferrand, Hôpital Estaing
🇫🇷Clermont-Ferrand cedex 1, France
Centre Leon Berard
🇫🇷Lyon cedex 8, France
Hokkaido University Hospital
🇯🇵Sapporo, Hokkaido, Japan
National Cancer Center Hospital East
🇯🇵Kashiwa-shi, Chiba, Japan
Hyogo Cancer Center
🇯🇵Akashi-shi, Hyogo, Japan
Yokohama City University Medical Center
🇯🇵Yokohama-shi, Kanagawa, Japan
Kansai Medical University Hospital
🇯🇵Hirakata-shi, Osaka, Japan
Kindai University Hospital
🇯🇵Osakasayama-shi, Osaka, Japan
Saitama Cancer Center
🇯🇵Kitaadachi-gun, Saitama, Japan
Shizuoka Cancer Center
🇯🇵Sunto-gun, Shizuoka, Japan
Osaka University Hospital
🇯🇵Suita-shi, Osaka, Japan
Steve Biko Academic Hospital
🇿🇦Tshwane, South Africa
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
Specialized Hospital for Active Treatment of Oncology - Haskovo EOOD
🇧🇬Haskovo, Bulgaria
Instituto Argentino de Diagnostico y Tratamiento IADT
🇦🇷Buenos Aires, Argentina
Azienda Ospedaliera San Giovanni Addolorata
🇮🇹Roma, Italy
National Hospital Organization Shikoku Cancer Center
🇯🇵Matsuyama-shi, Ehime, Japan
Hospital Universitario Fundacion Favaloro
🇦🇷Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Exelsus Oncologia Clinica
🇦🇷San Miguel de Tucuman, Tucuman, Argentina
Instituto Nacional de Cancer
🇧🇷Rio de Janeiro, Brazil
Jewish General Hospital
🇨🇦Montreal, Quebec, Canada
Multiprofile Hospital for Active Treatment Serdika EOOD
🇧🇬Sofia, Bulgaria
James Lind Centro de Investigacion del Cancer
🇨🇱Temuco, Cautín, Chile
The First Affiliated Hospital of Bengbu Medical College
🇨🇳Bengbu, Anhui, China
Chongqing University Three Gorges Hospital
🇨🇳Chongqing, Chongqing, China
The First Affiliated Hospital of Xiamen University
🇨🇳Xiamen, Fujian, China
Sun Yat-sen University Cancer Center
🇨🇳Guangzhou, Guangdong, China
Guangdong Provincial Peoples Hospital
🇨🇳Guangzhou, Guangdong, China
Fakultni nemocnice Hradec Kralove
🇨🇿Hradec Kralove, Czechia
Fakultni nemocnice Olomouc
🇨🇿Olomouc, Czechia
Centre Hospitalier Régional Universitaire de Lille - Hôpital Claude Huriez
🇫🇷Lille, France
Institut Gustave Roussy
🇫🇷Villejuif, France
University Hospital of Heraklion
🇬🇷Heraklion - Crete, Greece
Anticancer Hospital of Thessaloniki Theageneio
🇬🇷Thessaloniki, Greece
Azienda Unita Sanitaria Locale LE Presidio Ospedaliero Vito Fazzi Polo Oncologico Giovanni Paolo II
🇮🇹Lecce, Italy
Azienda Ospedaliera Universitaria Integrata di Verona Ospedale Civile Maggiore Borgo Trento
🇮🇹Verona, Italy
Kobe City Medical Center General Hospital
🇯🇵Kobe-shi, Hyogo, Japan
Gifu University Hospital
🇯🇵Gifu-shi, Gifu, Japan
Ishikawa Prefectural Central Hospital
🇯🇵Kanazawa-shi, Ishikawa, Japan
Kagawa University Hospital
🇯🇵Kita-gun, Kagawa, Japan
Kyoto University Hospital
🇯🇵Kyoto-shi, Kyoto, Japan
Osaka International Cancer Institute
🇯🇵Osaka-shi, Osaka, Japan
Jeonbuk National University Hospital
🇰🇷Jeonju-si, Jeollabuk-do, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Gyeonggi-do, Korea, Republic of
Severance Hospital Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
The Catholic University of Korea Seoul St Marys Hospital
🇰🇷Seoul, Korea, Republic of
Viesoji istaiga Klaipedos universitetine ligonine
🇱🇹Klaipeda, Lithuania
Nacionalinis vezio institutas
🇱🇹Vilnius, Lithuania
Wielkopolskie Centrum Onkologii imienia Marii Sklodowskiej-Curie
🇵🇱Poznan, Poland
Sandton Oncology Centre
🇿🇦Gauteng, South Africa
Hospital Universitario Reina Sofia
🇪🇸Cordoba, Andalucía, Spain
Netcare Milpark Hospital
🇿🇦Johannesburg, South Africa
Hospital Universitario Miguel Servet
🇪🇸Zaragoza, Aragón, Spain
Corporacio Sanitaria Parc Tauli
🇪🇸Sabadell, Cataluña, Spain
Hospital Regional Universitario de Malaga
🇪🇸Malaga, Andalucía, Spain
Hospital Universitario de Burgos
🇪🇸Burgos, Castilla León, Spain
Hospital Clinic i Provincial de Barcelona
🇪🇸Barcelona, Cataluña, Spain
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Cataluña, Spain
Hospital Universitari i Politecnic La Fe
🇪🇸Valencia, Comunidad Valenciana, Spain
Hospital Donostia
🇪🇸San Sebastian, País Vasco, Spain
Complexo Hospitalario Universitario de Ourense
🇪🇸Ourense, Galicia, Spain
Hospital General Universitario Gregorio Marañon
🇪🇸Madrid, Spain
Hospital Universitario Puerta de Hierro Majadahonda
🇪🇸Madrid, Spain
Hospital General Universitario Jose Maria Morales Meseguer
🇪🇸Murcia, Spain
Sahlgrenska Universitetssjukhuset
🇸🇪Göteborg, Sweden
Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation
🇨🇳Taoyuan, Taiwan
Doktor Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi
🇹🇷Ankara, Turkey
Memorial Ankara Hastanesi
🇹🇷Ankara, Turkey
Ankara Bilkent Sehir Hastanesi
🇹🇷Ankara, Turkey
Antalya Egitim ve Arastirma Hastanesi
🇹🇷Antalya, Turkey
Bezmialem Vakif Universitesi Hastanesi
🇹🇷Istanbul, Turkey
Dicle Universitesi Tip Fakultesi
🇹🇷Diyarbakir, Turkey
Istanbul Universitesi Cerrahpasa Tip Fakultesi
🇹🇷Istanbul, Turkey
Kocaeli Universitesi Tip Fakultesi Hastanesi
🇹🇷Kocaeli, Turkey
Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi
🇹🇷Istanbul, Turkey
Kartal Dr Lutfi Kirdar Sehir Hastanesi
🇹🇷Istanbul, Turkey
Izmir Ataturk Egitim ve Arastirma Hastanesi
🇹🇷Izmir, Turkey
Sakarya Egitim ve Arastirma Hastanesi
🇹🇷Sakarya, Turkey
Inonu Universitesi Turgut Ozal Tip Merkezi
🇹🇷Malatya, Turkey
Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi
🇹🇷Samsun, Turkey
Van Yuzuncu Yil Universitesi Dursun Odabas Tip Merkezi
🇹🇷Van, Turkey
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Inova Schar Cancer Institute
🇺🇸Fairfax, Virginia, United States
Clinica de Oncologia Reichow
🇧🇷Blumenau, Santa Catarina, Brazil
Mayo Clinic Rochester
🇺🇸Rochester, Minnesota, United States
FirstHealth Cancer Center
🇺🇸Pinehurst, North Carolina, United States
Mayo Clinic Arizona
🇺🇸Phoenix, Arizona, United States
University of California Los Angeles
🇺🇸Los Angeles, California, United States
Saint Francis Medical Group
🇺🇸Indianapolis, Indiana, United States
University of Michigan
🇺🇸Ann Arbor, Michigan, United States
St John of God Murdoch Hospital
🇦🇺Murdoch, Western Australia, Australia
Núcleo de Oncologia da Bahia
🇧🇷Salvador, Bahia, Brazil
Liverpool Hospital
🇦🇺Liverpool, New South Wales, Australia
Sunnybrook Research Institute Sunnybrook Health Sciences Centre
🇨🇦Toronto, Ontario, Canada
Christus Muguerza Clinica Vidriera
🇲🇽Monterrey, Nuevo León, Mexico
Filios Alta Medicina sa de cv
🇲🇽Monterrey, Nuevo León, Mexico
Kliniki Neuroradiochirurgii Spzoo Radom Centr Onkolo im Bohater Radomsk Czerwca -76 Szpital Specjal
🇵🇱Radom, Poland
Biokinetica SA
🇵🇱Jozefow, Poland
Centre Hospitalier Universitaire de Liege - Sart Tilman
🇧🇪Liege, Belgium
Universitair Ziekenhuis Leuven - Campus Gasthuisberg
🇧🇪Leuven, Belgium
Fundacion Cardiovascular de Colombia
🇨🇴Bucaramanga, Santander, Colombia
The Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and Tech
🇨🇳Wuhan, Hubei, China
Shanghai General Hospital
🇨🇳Shanghai, Shanghai, China
Shanghai East Hospital
🇨🇳Shanghai, Shanghai, China
Ruijin Hospital Shanghai Jiao Tong University School of Medicine
🇨🇳Shanghai, Shanghai, China
The First Affiliated Hospital Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
The Second Affiliated Hospital Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Fujian Cancer Hospital
🇨🇳Fuzhou, Fujian, China