Influence of Air Pollution on SPondyloarthritis Flare-ups and Resistance to Treatment

Not yet recruiting

• Conditions: Spondyloarthritis, Axial
• Interventions: Other: Assessment of exposure to air pollution

• Registration Number: NCT06077604
• Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Brief Summary

The relationship between exposure to air pollution and spondyloarthritis (SpA) has been poorly studied. Based on data from the literature on other inflammatory pathologies such as rheumatoid arthritis, we hypothesize that there is a relationship between exposure to air pollution and the risk of presenting a flare-up in SpA patients following and living in Franche-Comté (France).

Primary objective:The potential relationship between exposure to air pollution (nitrogen dioxide, fine particles with a diameter of less than 10 or 2.5 microns and Ozone) and the onset of a spondyloarthritis flare-up will be explored in patients with this pathology.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-10
• Study First Submitted: 2023-10-05
• Study First Submitted QC: 2023-10-05
• Last Update Submitted: 2023-10-05
• Study First Posted: 2023-10-11
• Last Update Posted: 2023-10-11
• Study Start: 2023-10-15
• Primary Completion: 2025-10-15
• Study Completion: 2025-10-15

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 175

Inclusion Criteria

• Diagnosis of Axial Spondyloarthritis (radiographic or non-radiographic) according to Assessment of SpondyloArthritis international Society (ASAS) criteria
• Patient having received a consultation / hospitalization during the period 2019-2022
• Patient enrolled in the MISTIC cohort
• Having lived in Franche-Comté during the 2019-2022 period.

Exclusion Criteria

• Other chronic inflammatory rheumatism (rheumatoid arthritis according to ACR 2010 criteria or psoriatic arthritis according to ClASsification criteria for Psoriatic ARthritis criteria)
• No inflammatory rheumatic disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with a diagnosis of Axial Spondyloarthritis	Assessment of exposure to air pollution	Patients with a diagnosis of Axial Spondyloarthritis, received in rheumatology consultation/hospitalization over the period 2019-2022 and living in Franche-Comté over the same period

Primary Outcome Measures

Name	Time	Method
Occurrence of a SpA flare-up	6 to 24 months	The occurrence of a SpA flare-up measured by disease activity, defined according to the BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) and/or ASDAS-CRP (Ankylosing Spondylitis Disease Activity Score - C reactive protein) scores (BASDAI score ≥4/10 and/or ASDAS-CRP score ≥2.1) according to ASAS group

Trial Locations

Locations (1)

Besançon University Hospital; 🇫🇷 Besançon, Bourgogne Franche Comté, France