Predicting Treatment Resistance in Schizophrenia

Completed

• Conditions: first episode psychosis; schizophrenia; 10039628

• Registration Number: NL-OMON48828
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 120

Inclusion Criteria

For patients:
- First episode psychosis
- Age 18-35 years old;For healthy contols:
- Age 18-35 years old

Exclusion Criteria

- Antipsychotic use longer than one year
- Dependence on other substances of abuse than nicotine or cannabis
- Use of amphetamine, cocaine or medication for ADHD (attention deficit hyperactivity disorder), since these drugs influence the dopamine system
- Neurological disorder (e.g. epilepsy) or evidence of brain damage
- Inability to provide informed consent;In addition to the exclusion criteria mentioned above, healthy control subjects are not allowed to have any kind of psychiatric disorder;Exclusion criteria directly related to MRI scanning:
- Contra-indications for MRI (including pacemaker, ferromagnetic implants, claustrophobia)
- Pregnancy;Exclusion criteria directly related to PET/CT scanning (for subgroup of 40 patients):
- Participation in a scientific examination where radiation was used, in the last year.
- Positive urine drug screen on the day of the PET/CT scan. Participants will be tested on cannabis, amphetamine, XTC, cocaine and opiates. Only recent cannabis use will be accepted.
- In women: positive pregnancy test on the day of the PET/CT scan and lactation.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Treatment resistance<br /><br>- Neuromelanin contrast ratio on nMRI<br /><br>- Glutamate/Creatine ratio on MRS in ACC<br /><br>- Plasma DDC activity<br /><br>- [18F]DOPA influx (Ki) value (for subgroup of 40 patients)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Side effects of antipsychotics<br /><br>- Symptom scores on PANSS<br /><br>- Neuropsychological ratings</p><br>