Therapie Resistentie Voorspellen bij Schizofrenie
Recruiting
- Conditions
- Schizophrenia, treatment resistance, psychosis, schizofrenie, therapie resistentie, psychose
- Registration Number
- NL-OMON21525
- Lead Sponsor
- Amsterdam UMC, University of Amsterdam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
First episode psychosis
- Age 18-35 years old
Exclusion Criteria
- Antipsychotic use longer than one year
- Dependence on other substances of abuse than nicotine or cannabis
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Treatment resistance<br /><br>- Neuromelanin contrast ratio on nMRI<br /><br>- Glutamate/Creatine ratio on MRS in ACC<br /><br>- Plasma DDC activity<br /><br>- [18F]F-DOPA influx (Ki) value (for subgroup of 40 patients)<br>
- Secondary Outcome Measures
Name Time Method - Side effects of antipsychotics<br /><br>- Symptom scores on PANSS<br /><br>- Neuropsychological ratings<br>