Ultrasound Guidance for Embryo Transfer

Not Applicable

Completed

• Conditions: Infertility
• Interventions: Procedure: Transvaginal Ultrasound Guided ET; Procedure: Transabdominal Ultrasound Guided ET

• Registration Number: NCT03851536
• Lead Sponsor: Menoufia University

Brief Summary

Randomized controlled study comparing the TVUS versus TAUS guidance during the procedure of embryo transfer.

Detailed Description

The aim of this study was to Compare between transvaginal and transabdominal ultrasound guided embryo transfer as regarding clinical pregnancy rate, patient comfort, time required for embryo transfer and endometrial visualization at time of embryo transfer.

Study Timeline

• Study Start: 2016-06-02
• Study First Submitted: 2019-02-05
• Primary Completion: 2019-02-15
• Study First Submitted QC: 2019-02-21
• Study First Posted: 2019-02-22
• Status Verified: 2019-03
• Study Completion: 2019-03-09
• Last Update Submitted: 2019-03-11
• Last Update Posted: 2019-03-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 178

Inclusion Criteria

All patients undergoing autologous ICSI and frozen embryo transfer (FET) cycles.

Exclusion Criteria

1. Cases of sever ovarian hyperstimulation requiring embryo cryopreservation
2. Gestational surrogate cycles
3. Oocyte donation cycles
4. Very poor responders
5. Patients with inadequate visualization of the uterus by ultrasound.
6. Very difficult mock embryo transfer.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Transvaginal Ultrasound Guided ET	Transvaginal Ultrasound Guided ET	Transvaginal ultrasound is used to guide ET
Transabdominal Ultrasound Guided ET	Transabdominal Ultrasound Guided ET	Transabdominal ultrasound is used to guide ET

Primary Outcome Measures

Name	Time	Method
Clinical pregnancy	3 weeks after Embryo transfer	A clinical pregnancy is a pregnancy that is confirmed by ultrasonic visualization of gestational sac or heartbeat.

Secondary Outcome Measures

Name	Time	Method
Degree of cramping and pain	During and immediately after ET	Degree of cramping and pain from 0 to 10 by visual analogue scale (VAS) where 0 is no pain and 10 unbearable pain.
Endometrial visualization at time of embryo transfer	During ET	Endometrial visualization at time of embryo transfer by ultrasound
Time required for ET	Time from when the catheter is handed to the transferring physician to the time it is returned to the transferring embryologist.	Time in seconds required for ET

Trial Locations

Locations (2)

Alexandria University; 🇪🇬 Alexandria, Egypt

Menoufia University; 🇪🇬 Shibīn Al Kawm, Monofiya, Egypt