Evalulation of Neutrophil Extracellular Traps (NETs) as prognostic markers after elective cardiac surgery
- Conditions
- SIRS -(systemic inflammatory Response Syndrome) and development of complications, such as Sepsis, after cardiac surgeryR65Systemic Inflammatory Response Syndrome [SIRS]
- Registration Number
- DRKS00009850
- Lead Sponsor
- Herzzentrum der Universität zu KölnKlinik für Herz- und Thoraxchirurgie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
Written informed consent from all participants or their legal representatives
Exclusion Criteria
- patients with known preexisting immunological disorders or systemic immunosuppressive medication
-no consent
-<18
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood samples will be collected from patients undergoing cardiac surgery at the day of admission, pre-OP, post-OP as well as at days 1, 3,, 5, 8 and 10 after surgery. NETs levels in patients' Plasma will be quantified by photometry and Real Time PCR, respectively.
- Secondary Outcome Measures
Name Time Method The scoring Systems CASUS, SOFA and APACHEII will be calculated. Plasma NETs level will be correlated to patients' scores