The role of neutrophil extracellular trap formation in sickle cell disease
Completed
- Conditions
- sickle cellsickle cell crisis10018902
- Registration Number
- NL-OMON40345
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
For patients:
1. High performance liquid chromatography confirmed diagnosis of HbSS, HbSC, HbS*0- or HbS*+-thalassemia genotype in SCD patients. 2. Written informed consent by the patient. 3.18 years and older
For healthy volunteers:
1. Age * 18 years; 2. WHO performance score 0; 3. healthy race-matched family member or acquaintance
Exclusion Criteria
For patients
1. HbSC or HbS*+- thalassemia genotype . 2. Pregnancy 3. Active cancer 4. Chronic HIV infection 5. Recent vaso-occlusive crisis (< 1 months) 6. Chronic transfusion therapy 7. Recent blood transfusion (< 3 months)
For healthy volunteers:
Carrier of sickle cell gene or other hemoglobinopathy
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>n.a.</p><br>
- Secondary Outcome Measures
Name Time Method <p>n.a.</p><br>