eutrophil extracellular trap formation and nuclease activity are decreased in vitro in septic patients
Recruiting
- Conditions
- R65A41.9Systemic Inflammatory Response Syndrome [SIRS]Sepsis, unspecified
- Registration Number
- DRKS00011104
- Lead Sponsor
- Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Agreement with participation in clinical trail, in case of minority agreement of both parents/legal guardians
Exclusion Criteria
immonusuppressive medications, leukemia
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.) the formation of neutrophil extracellular traps is altered in septic patients compared to healthy volunteers,<br>2.) the formation can be further modified following stimulation and<br>3.) the activity of nucleases differs.
- Secondary Outcome Measures
Name Time Method Impact of NETs on the course of sepsis and regulation of NET formation.