eutrophil and macrophage extracellular trap formatio

• Conditions: transplantatie; kidney transplantation

• Registration Number: NL-OMON56756
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 12

Inclusion Criteria

Healthy human volunteers, over 18 yr old
Informed consent obtained

Exclusion Criteria

* Smoking
* Use of chronic medication
* The use of any medication known to alter platelet function within the last
ten days prior to blood being drawn (i.e., Aspirin)
* The presence of any chronic or inflammatory diseases e.g. tuberculosis,
rheumatoid arthritis or hepatitis A, type 1 or 2 diabetes mellitus,
inflammatory bowel disease etc.
* Recent or heavy alcohol consumption (in the last 24 hours or *15 drinks/week)
* In females, pregnancy, the use of oral contraceptives or hormone replacement
therapy
* BMI above a normal range

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Quantification of extracellular traps formed in the supernatant of co-culture<br /><br>experiments of isolated neutrophils, macrophages, platelets and endothelial<br /><br>cells. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>