ET-SAH: Neutrophil Extracellular Traps in Subarachnoid Hemorrhage
- Conditions
- I60I63Subarachnoid haemorrhageCerebral infarction
- Registration Number
- DRKS00025118
- Lead Sponsor
- niversitätsklinikum Augsburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Age =18 years
- Spontaneous non-traumatic subarachnoid hemorrhage (aneurysmal or non-aneurysmal)
- Patient or patient representative giving informed consent
- Study enrollment within 48 hours from symptom onset
Exclusion Criteria
- Recent (within the past 3 months) history of: ischemic stroke, hemorrhagic stroke, myocardial infarction, venous thromboembolism.
- Any past medical history of: rheumatoid arthritis, systemic lupus erythematosus, cancer, hereditary coagulopathy, subarachnoid hemorrhage
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The plasma concentration of the following biomarkers on post subarachnoid hemorrhage day 2, day 7, and day 10 (the day of the ictus is counted as day 0). Each blood collection can be performed , +-1 day. <br><br>Analyzed biomarkers:<br>- Cell-free DNA<br>- Nucleosomes / histones <br>- DNA-myeloperoxidase (MPO) complexes or DNA-neutrophil elastase (NE) complexes<br>- Citrullinated histones<br>- Peptidylarginine deaminase 4 (PAD4)
- Secondary Outcome Measures
Name Time Method Assessment for delayed cerebral ischemia on routinely obtained imaging (computed tomography or magnetic resonance imaging of the brain) at any point in time between 48 hours after aneurysm occlusion and 6 weeks after the index bleed, whenever deemed clinically appropriate. <br>The radiological assessment of delayed cerebral ischemia follows the published consensus definition of the Neurocritical Care Society multidisciplinary research group.