Explorative study of neutrophil extracellular traps formation and their influence on coagulation in human sepsis and systemic inflammatio

• Conditions: A41; Other sepsis

• Registration Number: DRKS00013584
• Lead Sponsor: niversitätsklinikum Gießen und Marburg, Standort GießenKlinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-07-11
• Study Completion: 2019-04-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

age>18 years
signed informed consent

Exclusion Criteria

age <18 years, pregnancy, severe valvular heart disease (III°), active autoimmune disorders, active solid or hematogenic malignancies, disorders with need of immunosuppressive therapy

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ETs in peripheral blood (quantified with flow cytometry)

Secondary Outcome Measures

Name	Time	Method
1. Severity of coagulopathy (thrombelastography) <br>2. Amount of free circulating mitochondrial DNA (qPCR)<br>3. mount of free circulating and mitochondrial ROS (ESR)<br>4. Severity of peripheral perfusion problems (O2C)