Measuring static and dynamic cerebral autoregulation intraoperatively in volunteers at different steady-state MBP.
- Conditions
- Cerebral autoregulationRegulation of cerebral blood flow10007963
- Registration Number
- NL-OMON46058
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 66
ASA-I or ASA-II, willing and able to give written informed consent, scheduled for elective, non-cardiothoracic surgery under general anaesthesia and age 18 years and above.
Patient related
* Unable/ unwilling to participate
* ASA-III or higher
* Age < 18 years
* History of: uncontrolled hypertension, diabetes, Parkinson*s disease, uncontrolled cardiac arrhythmia, Pure autonomic failure (formerly called idiopathic orthostatic hypotension), Multiple system atrophy with autonomic failure (formerly called Shy-Drager syndrome), Addison*s disease and hypopituitarism, pheochromocytoma, peripheral autonomic neuropathy (e.g., amyloid neuropathy, idiopathic autonomic neuropathy), known cardiomyopathy, extreme left ventricle hypertrophy or ejection fraction < 30%, proven or suspected allergy for any of the medication used during induction of anaesthesia, malignant hyperthermia.
* Unability to record transcranial Doppler ultrasound due to anatomical variance (~5% of population)
* Contra-indications for intravenous or inhalational anaesthesia.
Surgery related
* Day case surgery
* Laparoscopy with CO2 insufflation
* Extreme positioning during surgery (head-down/up tilt, lateral decubitus position, prone)
* Surgery < 60 minutes.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Differences in MAP, cerebral oxygenation, MCAV and dynamic and static cerebral<br /><br>autoregulation indices during blood pressure modifications.</p><br>
- Secondary Outcome Measures
Name Time Method <p>nvt</p><br>