Effects of inhaled essential oils on central nervous system, autonomic nervous system, emotional states and reaction time

Not Applicable

Completed

• Conditions: Healthy participants

• Registration Number: TCTR20181119005
• Lead Sponsor: Chulalongkorn university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-11-19
• Study Completion: 2019-06-22
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

1. Male or female age between 18 and 25 years
2. Participants are right-handed that is confirmed by Edinburge Handedness Inventory test (83).
3. Participants have normal sense of smell that is confirmed by “n- butyl alcohol method test” before the experiment. This test measures the lowest concentration of a stimulus that can be distinguished between n-butyl alcohol and water. The normal participant can separate two odors at concentration lower than Step 6 (5.48×10-3v/v) of n- butyl alcohol in water (84-85).
4. Participants have no upper respiratory diseases, otorhinolaryngological infection, neurological diseases, hypertension or cardiovascular disease and physical conditions that may affect the sense of smell.
5. Participants have no history of neurological illness, epilepsy or loss of consciousness longer than 30 minutes.
6. Not taking CNS medication or presently taking recreational drugs
7. Normal blood pressure (systolic should not be higher than 140 mmHg,
diastolic not be higher than 90 mmHg)
8. Heart rate normal rhythm (should not be higher than 90)
9. Body mass index 18.5 †22.9 Kg/M2
10. Non †smoker
11. Each potential participant of will be asked to inhale the mixture of sweet almond oil and selected essential oil to fill out the pleasantness from “Odour familiarity five-point Likert scale”. Only the potential participants who indicated oil pleasantness within the target level range of 2-4 will be recruited as participants.

Exclusion Criteria

1. Female who are presently menstruating
2. Have drowsiness before or during experiments experiment
3. Taking caffeine or alcohol for two hours before the test
4. Have abnormal brain wave which is detected by electroencephalogram
5. Participants who are allergic to essential oils will be excluded from the experiment

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Brain wave activity 1 hour per time Electroencephalography (EEG) recording,Autonomic nervous system (skin temperature (ST), breathing rate (BR), heart rate (HR) and blood pre) 30 minutes per time BIOLIGT M7000 Muti-Parameter Patient Mornitor,Emotion states 2-5 minutes per time Emotion questionnaire ,Reaction time 5 minutes per time The Deary-Liewald task

Secondary Outcome Measures

Name	Time	Method
/A N/A N/A