Evaluation of the cerebello-rubro-thalamic tract after (sub)thalamotomy.

Completed

• Conditions: tremor; 10028037; shaking

• Registration Number: NL-OMON43426
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 19

Inclusion Criteria

- Adult patients (>18 years old).
- Treatment for tremor with (sub)thalamotomy in the UMCG.
- Written informed consent.

Exclusion Criteria

- Contra-indications to MRI examination (e.g. heart pacemaker, metal foreign body in eye, aneurysm clip in brain, severe claustrophobia).
- Implantation of DBS electrodes
- Patients with a life expectancy less than 6 months
- Patients physically not able to lie flat for one hour

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>In all patients: relation between tremor severity and localization of the<br /><br>lesion. Relation between clinical tremor severity and radiographic (DTI)<br /><br>features of the cerebello-rubro-thalamic tract.<br /><br><br /><br>- The difference in localization of the lesioned area in the brain towards the<br /><br>preoperative assessed target measured in millimetres.<br /><br>- The volume of the dentato-rubro-thalamic tract involved in the lesioned area<br /><br>and compared to the contralateral side.<br /><br>- Tremor severity as measured by accelerometers (amplitude and frequency) and<br /><br>the Bain & Findley Clinical Tremor Rating Scale.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Patient satisfaction after (sub)thalamotomy using a short questionnaire (VAS<br /><br>score).</p><br>