Immunohematology in COVID-19 Patients: A Hospital-based Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 2,000
- 试验地点
- 1
- 主要终点
- ABO and Rh distribution
研究概览
简要总结
This is a hospital-based retrospective cohort study and the Immunohematologic characteristics of COVID-19 patients will be investigated systematically.
详细描述
This is a hospital-based retrospective cohort study and the Immunohematologic characteristics of COVID-19 patients will be investigated systematically. In this study, we will seek to understand the association between SARS-CoV-2 infection and blood groups and explore the Anti-A and Anti-B effects in COVID-19 patients with graded severity. We will analyze the transfusion requirement and the clinical recurrences of COVID-19 patients. The discrepancy of blood group phenotypes in COVID-19 patients with graded severity will be also analyzed on the molecular level. This retrospective cohort study was conducted using electronic health recording data in Tongji Hospital. The clinical characteristics for all eligible patients will be retrieved. The records will be verified to avoid possible bias. Data collection was carried out independently by two investigators and reviewed by two different investigators.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The patients who were diagnosed with COVID-19 following the WHO interim guidelines (https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novelcoronavirus-(ncov)-infection-is-suspected. 2020.)
排除标准
- •Male or female patients <18 years of age
结局指标
主要结局
ABO and Rh distribution
时间窗: 1 year
ABO and Rh phenotype distribution refers to the phenotype frequency of the ABO and Rh subtypes in severe and non-severe COVID-19 patients
ABO antibody titers
时间窗: 1 year
ABO antibody titers refers to both anti-A and anti-B antibodies in severe and non-severe COVID-19 patients
次要结局
- Transfusion incidence(1 year)
- outcomes of SARS-CoV-2 infection(1 year)
- Patients with coagulopathy(1 year)
- Leukocyte and neutrophil counts(1 year)
- Polymorphism of ABO blood group(1 year)
研究者
LI YAN
professor
Tongji Hospital