the Effect of Oral Vasopressors for Liberation From IV Vasopressors in Spinal Shock
Phase 2
- Conditions
- Spinal Shock
- Interventions
- Registration Number
- NCT04586790
- Lead Sponsor
- Ahmed talaat ahmed aly
- Brief Summary
the study is developed to evaluate the effect of use of oral vasopressors (midodrine versus minirin) on weaning ICU patients from IV vasopressors (noradrenaline) and compare between them for efficacy in shortage the duration of IV vasopressor and has low complications and side effects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
- Age of 18 - 60 years.
- Patients of both genders.
- Patients diagnosed by spinal shock and they are in the recovery stage .
Exclusion Criteria
- Patient refusal.
- Anuric or oliguric patients or patients with chronic kidney disease.
- Patients with allergy to medication included in the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description minirin group Minirin oral tablet the patients will receive minirin 60 µg PO q8hr with gradual weaning of IV noradrenaline after receiving 4 doses of oral minirin midodrine group Midodrine Oral Tablet midodrine group will receive midodrine 10 mg PO q8hr with gradual weaning of IV noradrenaline after receiving 4 doses of oral midodrine control group Nor-Adrenaline the patients will receive IV nor-adrenaline and are gradually weaning from it according to routine hospital care without adding oral midodrine or oral minirin .
- Primary Outcome Measures
Name Time Method liberation the patient from IV vasopressors with maintaining hemodynamics. 48 hrs Blood pressure will be assessed regularly every 15 minutes
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ahmed Talaat Ahmed
🇪🇬Assiut, Egypt