Effects of Antimicrobial Peptides Application after Non-surgical Periodontal Therapy on Treatment of Stage III and Grade B Periodontitis: A Randomized Clinical and Microbiological Trial
Phase 3
Recruiting
- Conditions
- In this randomized clinical trial, we aimed to evaluate the effects of AMPs as an addition to SRP on clinical parameters and microbiological biofilms in patients with Stage III and Grade B periodontitis.
- Registration Number
- JPRN-UMIN000047711
- Lead Sponsor
- Department of Periodontics,Beijing Stomatological Hospital, Capital Medical University
- Brief Summary
Probing depth:the reduction was significantly higher in the AMP group than in the other two groups (p<0.001). Attachment level and Bleeding index: The AMP group at 90 days not only showed an increase in attachment gain and reduction in the bleeding index compared with the baseline of this group but also showed a significantly higher increase than the other two groups (p< 0.05).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 51
Inclusion Criteria
Not provided
Exclusion Criteria
The exclusion criteria were: (1) acute oral lesions or necrotizing ulcerative periodontitis, (2) having received antibiotics within 6 months or the need for antibiotic coverage during experiment, (3) being allergic to minocycline, (4) no orthodontic treatment, (5) a history of systemic diseases, (6) pregnancy, (7) smoker
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method probing depth,clinical attachment level,Bleeding index, and Microbiological results
- Secondary Outcome Measures
Name Time Method