Sleep Disorders and the Onset and Progression of ALS
- Conditions
- Amyotrophic Lateral Sclerosis
- Interventions
- Behavioral: sleep disorder
- Registration Number
- NCT04952038
- Lead Sponsor
- Peking University Third Hospital
- Brief Summary
200 cases of ALS patients were collected to explore whether sleep disorders are related to earlier onset age, and whether sleep disorders accelerate the progress of ALS and shorten the survival time of ALS patients.
- Detailed Description
200 patients with ALS were collected. 1) sleep disorders were assessed by Pittsburgh sleep quality index (PSQI) and Epworth Sleepiness Scale (epworth) at baseline Sleeping Scale，ESS）； 2) Name, age, gender and onset site were collected to explore whether sleep disorders were associated with earlier onset age; 3) The patients' function (ALSFRS-R) at baseline and every 3 months within 2 years were collected, and the end-point time (death and invasive breathing) was recorded to evaluate whether sleep disturbance accelerated the decline of patients' function and shortened their short-term survival.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
- Patients who have been diagnosed in the Department of Neurology of the Third Hospital of Beijing Medical University since August 2020. The clinical diagnosis of patients with amyotrophic lateral sclerosis includes: probable and define;
- Informed consent has been signed.
- Those who can not cooperate to complete the scale and receive follow-up.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description ALS patients with sleep disorder sleep disorder -
- Primary Outcome Measures
Name Time Method ALSFERS-R 2 years ALS functional score
end point event 2 years death or invasive breathing
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Peking University Third Hospital
🇨🇳Beijing, Beijing, China