Molecular and Functional Neurobiology of Physical Exercise

Not Applicable

Completed

• Conditions: Physical Exercise Behavior (Liking/Aversion)
• Interventions: Behavioral: Exercise

• Registration Number: NCT02615756
• Lead Sponsor: Turku University Hospital

Brief Summary

In this study, we use positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to study brain mechanisms that contribute to physical exercise-induced reward. We examine whether acute physical exercise releases endogenous opioids in the brain, and whether it modulates brain responses to viewing appetizing foods. Unraveling these mechanism are instrumental from a public health perspective, given the undisputed positive health effects of physical exercise.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-04
• Study First Submitted: 2014-09-10
• Study First Submitted QC: 2015-11-23
• Study First Posted: 2015-11-26
• Primary Completion: 2018-06
• Study Completion: 2018-06
• Status Verified: 2021-03
• Last Update Submitted: 2021-03-04
• Last Update Posted: 2021-03-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 24

Inclusion Criteria

1. Native Finnish speaker
2. Age > 18 years
3. Western Caucasian origin

Exclusion Criteria

1. Age < 18 or > 65
2. History or current mental disorder
3. BMI > 27 kg/m2
4. Use of drugs that influence the central nervous system, including nicotine
5. Poor compliance
6. Any chronic medical defect or injury which hinder or interfere everyday life
7. Eating disorder
8. Current or past excessive use of alcohol or substance abuse
9. Past dose of radiation from medical research such that the annual effective dose will exceed 10 mSv
10. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
11. Presence of any ferromagnetic objects that would make MR imaging contraindicated

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Physical exercise	Exercise	-

Primary Outcome Measures

Name	Time	Method
Binding of [11C]carfentanil in brain confirmed by positron emission tomography	Baseline and 20 min after physical exercise completion	Change in binding of \[11C\]carfentanil in baseline and 20 min after physical exercise completion

Trial Locations

Locations (1)

Turku PET Centre; 🇫🇮 Turku, Finland