abelled-butyrate and labelled-glucose breath testing to detect mesenteric ischemia, a proof of principle study in healthy volunteers

• Conditions: Chronic mesenteric ischemia; intestinal oxygen shortage; 10018031

• Registration Number: NL-OMON50079
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

* *18 years of age
* Experience with cycling
* Signed informed consent
* Unremarkable medical history (no gastrointestinal diseases, no cardiac or
pulmonary diseases)
* No gastrointestinal complaints

Exclusion Criteria

* Unable to sign informed consent
* Pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The possibility of detecting mesenteric ischemia by 13C-butyrate, 13C-glucose,<br /><br>and 13C-glucose and D-butyrate breath testing by differences in timing and<br /><br>concentration of the peak of expired 13CO2 and DHO between control and<br /><br>intervention group.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To determine the optimal oral dose of D-butyrate for the measurement of<br /><br>D-butyrate metabolism in enterocytes by performing a DHO breath test</p><br>