ong-term cardio- and neurovascular effects of radiotherapy and chemotherapy in patients with Hodgkin's lymphoma
Completed
- Conditions
- Hodgkin's disease1002531910003216
- Registration Number
- NL-OMON31544
- Lead Sponsor
- Interne Geneeskunde
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
Patients who have been treated for Hodgkin's lymphoma in the past and who survived at least 2 years. Age> 18 years.
Exclusion Criteria
Psychiatric disease or inability to give informed consent.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main parameters are the difference in IMT, the elasticity,the degree of<br /><br>stenosis<br /><br>between the irradiated group and the non-irradiated HL group and to the control<br /><br>population.<br /><br>The other main parameter is the extent of coronary atherosclerosis on MRI in<br /><br>the two patients groups.</p><br>
- Secondary Outcome Measures
Name Time Method <p>To investigate if inflammatory markers which are know to be increased in<br /><br>age-related atherosclerosis are also increased in RT-induced atherosclerosis.<br /><br>The amounts of cerebrovascular events; i.e. TIA or CVA and of cardiovascular<br /><br>disease; i.e. angina pectoris, myocardial infarction, cardiomyopathy, cardiac<br /><br>failure, rhythm-, conduction abnormalities and valvular dysfunction will be<br /><br>studied. Also endocrine dysfunction will be assessed.</p><br>