The Effect of Adding Epinephrine To Combination of 0.5% Bupivacaine and Dexmedetomidine in Epidural anaesthesia for Lower Limb Surgeries - A Prospective, Double Blinded Randomized Control Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Duration of analgesia
研究概览
简要总结
This study is designed to evaluate epidural anaesthesia and postoperative analgesia by adding epinephrine to combination of bupivacaine and dexmedetomidine.
In earlier studies, the use of dexmedetomidine as an adjuvant to bupivacaine is a good alternative to other adjuvants like fentanyl in epidural anesthesia, and dexmedetomidine has an edge over fentanyl as an adjuvant when used with bupivacaine in epidural anesthesia. Whereas, addition of epinephrine to bupivacaine resulted in longer duration of analgesia in comparison to plain bupivacaine in labor analgesia.
We hypothesized that epidural 0.5% bupivacaine with dexmedetomidine and adrenaline 1:1000 would be comparable to 0.5% bupivacaine with dexmedetomidine and normal saline, for the efficacy of anesthesia and analgesia, and in addition would provide a better postoperative recovery profile and readiness for discharge.The purpose of the present study is to observe the effect of mentioned study drugs in epidural anaesthesia for duration of sensory and motor block with duration of analgesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 15.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA 1 & 2 Lower limb surgery of probable duration of 2hrs.
排除标准
- •Patients refusal Contradiction to regional anaesthesia Coagulopathy History of significant coexisting diseases like ischemic heart disease, hypertension, impaired renal functions, rheumatoid arthritis, and severe liver disease Pregnant patients Chronic alcoholics and malnourished patients Atrioventricular block, incomplete or partial heart blocks or intake of beta-blockers.
结局指标
主要结局
Duration of analgesia
时间窗: After 2 hours every 15 minutes
次要结局
- Duration of sensory block & motor block(After 2 hours every 15 minutes)