Intestinal microbiota, executive functioning and micronutrient status in enduring anorexia nervosa: a pilot study

Completed

• Conditions: anorexia nervosa; 10014067

• Registration Number: NL-OMON53103
• Lead Sponsor: Stichting Rivierduinen

Brief Summary

Trial ended prematurely

Detailed Description

Not available

Study Timeline

• Study Completion: 2023-11-27
• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

-enduring anorexia nervosa (at least two year continuous presence) according to
DSM-5 criteria
-age between 18 and 60 years

Exclusion Criteria

-renal failure
-liver disease
-chronic diarrhea
-current laxative use
-smoking > 5 cigarettes/day
-alcohol intake > 10.0 g/day (equals one standard glass alcohol)
-current use of multivitamins
-pregnancy
-IQ below 85

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Intestinal microbiota: Bacterial DNA will be extracted from stool samples.<br /><br>Neuropsychological Tasks (Executive functions): Wisconsin Card Sorting Test<br /><br>(WCST), Trail Making Test (TMT), Go/No Go task, Iowa Gambling Task (IGT).<br /><br>Questionnaires (Executive functions): Behavior Rating Inventory of Executive<br /><br>Function Adult Version (BRIEF-A-SR), Dickman Impulsivity Inventory (DII).<br /><br>Micronutrient status: Vitamin B1, vitamin B6, vitamin B12, vitamin D, folic<br /><br>acid, magnesium and zinc.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Eating disorder psychopathology: Eating Disorder Examination Questionnaire<br /><br>(EDE-Q)<br /><br>Depressive symptoms: Inventory of Depressive Symptomatology (IDS-SR)<br /><br>IQ: Nederlandse Leestest voor Volwassenen<br /><br>Food intake: dietary history with check/crosscheck (food diary during three<br /><br>days)</p><br>