Physical Activity in Overweight Girls: Implications for Reversing Risk Factors for Type 2 Diabetes
Not Applicable
Completed
- Conditions
- Abdominal ObesityPhysical Activity
- Interventions
- Other: Aerobic exerciseOther: Resistance ExerciseOther: Control
- Registration Number
- NCT01323088
- Lead Sponsor
- University of Pittsburgh
- Brief Summary
In this randomized controlled trial, we will examine the effect of a 3-month exercise training (aerobic exercise versus resistance exercise) without calorie restriction on total and regional adiposity, ectopic fat in the liver and skeletal muscle, and risk of type 2 diabetes in overweight girls.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 44
Inclusion Criteria
- Healthy overweight (BMI >-95th) youth between 12 and 18 years of age
- Waist circumference >-75th percentile
- Sedentary (no structured exercise >2 times/week for past 6 months)
- Non-smokers, non-diabetic, no medical conditions
- Weight stable for past 3 months
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Exclusion Criteria
- Smokers
- Diabetes
- Psychiatric disorders
- Syndromic obesity
- Pregnancy
- Taking medications known to affect study outcomes
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Aerobic Exercise Aerobic exercise - Resistance Exercise Resistance Exercise - Control Control Standard care control (no-exercise)
- Primary Outcome Measures
Name Time Method Abdominal obesity, visceral fat 3 month
- Secondary Outcome Measures
Name Time Method insulin sensitivity by a 3-hour hyperinsulinemic-euglycemic clamp, oral glucose tolerance test, liver fat and intramyocellular lipid by 1H-magnetic resonance spectroscopy. 3 month
Trial Locations
- Locations (1)
Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine
🇺🇸Pittsburgh, Pennsylvania, United States