A prospective clinical and radiological study of incidental cerebral small vessel disease: Aspirin versus Cilostazol (PACCS)

Not Applicable

Not yet recruiting

• Conditions: Nervous System Diseases

• Registration Number: PACTR202301861240705
• Lead Sponsor: Hany Aref

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-12-21
• Last Update Posted: 2023-05-29

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 220

Inclusion Criteria

Patient aged 45 or Above suffering from incidental cerebral SVD
Patients presenting with slowly progressive cognitive, urinary, gait abnormalities and/or depression, rather than acute stroke presentation.
MRI brain suggestive of small vessel disease in the form of deep white matter hyperintensities (WMH), lacunes, cerebral microbleeds, enlarged Virchow spaces, silent small subcortical infarct

Exclusion Criteria

? Patients with acute onset stroke of any source (Ex: CADASIL)
? Patients with past history of acute large vessel stroke
? Patients with large vessel occlusion or stenosis >50%
? Contraindication to MRI (as pacemakers or metal plates and screws)
? Alcohol addiction or substance abuse (to exclude substance induced vasculitis)
? Any neurological disease affecting white matter (eg; Multiple sclerosis, sarcoidosis, etc),
? Any neurological disease presenting with symptoms similar to cerebral small vessel disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified