Generation 100: How Exercise Affects Mortality and Morbidity in the Elderly: A Randomized Control Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- total blood volume
研究概览
简要总结
Hypothesis: Exercise will reduce morbidity and mortality rates in an elderly population. The extent of reduction will be intensity dependent.
As part of the "Generation 100" study, this sub-study project will investigate the effect of exercise on blood volume, cardiopulmonary health and heart function in healthy aging. Objective is to determine the acute effect of one endurance training session on blood volume in healthy elderly. The working hypothesis is that one interval training session increases total blood volume by 10% in healthy elderly, and that there will be no change after moderate continuous training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 70 Years 至 75 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ability to walk at least 1km,
- •born in 1938,1939,1940,1941 or 1942
- •Sufficiently good health to be able to take part in the study, as determined by the researchers
排除标准
- •Illness or disability that precludes exercise or hinders completion of the study
- •Uncontrolled hypertension
- •Symptomatic valve disease, hyper tropic cardio-myopathy or unstable angina
- •Active cancer
- •Test results indicating that study participation is unsafe
- •Inclusion in other studies conflicting with participation in this one
研究组 & 干预措施
high intensity interval training
one interval training session with 1 x 4 and 4 x 4 minutes interval training at 90-95% of peak heart rate
干预措施: high intensity interval training (Behavioral)
high intensity interval training
one interval training session with 1 x 4 and 4 x 4 minutes interval training at 90-95% of peak heart rate
干预措施: moderate intensity training (Behavioral)
moderate intensity training
45 minutes of moderate continuous training at 75% of maximal heart rate
干预措施: moderate intensity training (Behavioral)
moderate intensity training
45 minutes of moderate continuous training at 75% of maximal heart rate
干预措施: high intensity interval training (Behavioral)
结局指标
主要结局
total blood volume
时间窗: 24 hours
carbon monoxide-rebreathing spirometry (Bayreuth, Germany)
次要结局
- hemoglobin volume(24 hours)