Generation 100: How Exercise Affects Mortality and Morbidity in the Elderly: A Randomized Control Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 1,567
- 试验地点
- 1
- 主要终点
- Mortality
研究概览
简要总结
Hypothesis: Exercise will reduce morbidity and mortality rates in an elderly population. The extent of reduction will be intensity dependent.
详细描述
Literature lacks large controlled randomized studies that look at the effect of exercise training on morbidity and mortality. Generation 100 will be the first randomized, controlled clinical study where the primary objective is to study the effects of exercise training on morbidity and mortality in the elderly. Furthermore, the researchers will investigate whether there is a relationship between the exercise intensity and health benefits, with particular focus on major health problems in the elderly population. In addition to being a study, this is also an initiative to improve public health in all healthy individuals between 70-75 years of age in the Trondheim municipality. The participants will either be randomized to supervised exercise or follow current guidelines for physical activity on their own. Clinical examinations, as well as questionnaires, will be administered to all participants at baseline, after one year, after three years, and after five years. Additionally, participants will be followed-up by linking to relevant registers for up to 20 years.
Also data will be collected with the purposes of (a) investigating genetic predisposition for fitness and cardiovascular diseases, and (b) identification of potential targets for therapies.
The study seeks to determine if exercise training gives the seniors a longer active and healthy life.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 70 Years 至 76 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Born in 1936, 1937, 1938, 1939, 1940, 1941 or 1942
- •Able to complete the exercise program (determined by the researchers).
排除标准
- •Illness or disabilities that preclude exercise or hinder completion of the study
- •Uncontrolled hypertension
- •Symptomatic valvular, hypertrophic cardiomyopathy, unstable angina, pulmonary hypertension, heart failure and severe arrhythmia
- •Diagnosed dementia
- •Cancer that makes participation impossible or exercise contraindicated. Considered individually, in consultation with the attending physician.
- •Chronic communicable infectious diseases.
- •Test results indicating that study participation is unsafe
- •Participation in other studies conflicting with participation in Generation 100
研究组 & 干预措施
high intensity aerobic training
Exercise intervention: High intensity group performing high intensity training where they are required to raise their heart rate several times during the workout and reach perceived exhaustion of 16 on a Borg scale
干预措施: Exercise intervention (Other)
Moderate intensity training
Exercise intervention: Moderate intensity Group of people asked to perform moderate training where they exercise at a given intensity (moderate as per Borg scale) for a certain amount of time
干预措施: Exercise intervention (Other)
结局指标
主要结局
Mortality
时间窗: 5 years follow up
using data from governmental registers
次要结局
- General measurements(1 year follow up, 3 years follow up, 5 years follow up)
- Epigenetics(1 year follow up, 3 years follow up, 5 years follow up)
- Morbidity(3 and 5 years)
- Mortality and Morbidity(10 years)
- General measurements(1 year follow up, 3 years follow up, 5 years follow up)
- Epigenetics(1 year follow up, 3 years follow up, 5 years follow up)
- Morbidity(3 and 5 years)
- Mortality and Morbidity(10 years)