Propofol and Sevoflurane Anesthesia in Colorectal Cancer Surgery: Incidence of Acute Kidney Injury
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 4,000
- 试验地点
- 1
- 主要终点
- Acute Kidney Injury
研究概览
简要总结
The goal of this observational study is to compare anesthetic modalities (intravenous propofol anesthesia with sevoflurane gas anesthesia) in patients who underwent colorectal cancer resection surgery regarding the outcome of acute kidney injury.
The main questions it aims to answer are:
- is there a difference in acute kidney injury incidence in the two anesthetic modalities?
- is there a difference in plasma creatinine between the two anesthetic modalities?
- are there any patient characteristics or intraoperative factors that effect the incidence of acute kidney injury in either anesthetic modality?
The study will analyze data from the CAN clinical trial database. (Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia, NCT01975064)
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •colorectal surgery and participant in the CAN trial
排除标准
- •missing blood samples
研究组 & 干预措施
Sevoflurane
The group of patients which received sevoflurane as randomized anesthetic modality.
干预措施: Anesthesia Agent (Drug)
Propofol
The group of patients which received propofol as randomized anesthetic modality.
干预措施: Anesthesia Agent (Drug)
结局指标
主要结局
Acute Kidney Injury
时间窗: Within 10 days of surgery
Compare the incidence of AKI (n, %) in the two anesthetic modalities. Number of participants (n, %) with AKI and number of participants (n, %) with AKI stage 1-3 within the different anesthetic modalities at 0-3 days and 4-10 days postoperatively. KDIGO (Kidney Disease: Improving Global Outcome) criteria for plasma creatinine are used as criteria for AKI. The highest value of plasma creatinine within the time frame will be used to define AKI stage.
Changes in plasma creatinine
时间窗: Within 30 days of surgery
Changes in plasma creatinine over time in both groups of anesthesia. Plasma creatinine from preoperative, postoperative after 0-3 days, postoperative 4-10 days and after 30 days. Maximum plasma creatinine for each participant at these time point will be used in the regression analysis.
次要结局
- AKI incidence in the cardiovascular disease population(Within 10 days of surgery)
- Association of sex on AKI incidence(Within 10 days of surgery)
- Association of age on AKI incidence(Within 10 days of surgery)