Vaginal and Oral Microbiome Crosstalk

Recruiting

• Conditions: Vaginal Discharge; Healthy
• Interventions: Other: vaginal and oral swab sample, questionnaire; Other: papa smear

• Registration Number: NCT02898818
• Lead Sponsor: Turku University Hospital

Brief Summary

To study the vaginal and oral microbiome by swab samples. On selected cases, also papa smear will be studied.

Detailed Description

To study the vaginal and oral microbiome by swab samples and on selected groups, by papa smear test, to find out the constitution of normal and vaginal microbiome and the cross-talk between oral and vaginal mucosa. To find out about the impact of human papilloma virus on the microbiome and vice versa.

Study Timeline

• Study First Submitted: 2016-09-07
• Study First Submitted QC: 2016-09-07
• Study First Posted: 2016-09-13
• Study Start: 2017-04-19
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-28
• Last Update Posted: 2025-05-01
• Primary Completion: 2026-09
• Study Completion: 2027-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 520

Inclusion Criteria

• patients coming to Turku University Hospital Dermato-Venereology or Gynaecology Departments or to family planning clinics in The wellbeing services county of Southwest Finland for previously mentioned reasons

Exclusion Criteria

• those not meeting the criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
symptomless	vaginal and oral swab sample, questionnaire	vaginal and oral swab sample, questionnaire
no atypical papa smear	vaginal and oral swab sample, questionnaire	vaginal and oral swab sample, questionnaire, papa smear
atypical papa smear	vaginal and oral swab sample, questionnaire	vaginal and oral swab sample, questionnaire, papa smear
no atypical papa smear	papa smear	vaginal and oral swab sample, questionnaire, papa smear
vaginal discharge	vaginal and oral swab sample, questionnaire	vaginal and oral swab sample, questionnaire
atypical papa smear	papa smear	vaginal and oral swab sample, questionnaire, papa smear
lichen planus	papa smear	vaginal and oral swab sample, questionnaire, papa smear
lichen planus	vaginal and oral swab sample, questionnaire	vaginal and oral swab sample, questionnaire, papa smear

Primary Outcome Measures

Name	Time	Method
microbiome, papa smear	5 years	Differences in microbiome and papa smear

Trial Locations

Locations (1)

Turku University Hospital; 🇫🇮 Turku, Finland