A Cross-over study to compare the Lung Flute method with hypertonic saline inhalation for the examination of M. tuberculosis in induced sputum
- Conditions
- Pulmonary tuberculosis
- Registration Number
- JPRN-UMIN000004676
- Lead Sponsor
- Sputum Induction Research Group
- Brief Summary
Total of 63 patients were analyzed. A crossover study of the Lung Flute method (LF) and hypertonic saline inhalation (HSI) demonstrated no significant difference in grading of smear, positive culture rate, time to positivity (days), and PCR positivity between LF and HSI. The Lung Flute method was equivalent in terms of bacteriological diagnosis to hypertonic saline inhalation in hospitalized patients with tuberculosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 120
Not provided
1. ABF sputum smear 3+ before admission 2. Patients who expectorate sputum at any time 3. Laryngeal tuberculosis 4. Bronchial asthma 5. Hemoptysis 6. Respiratory failure (Spo2 below 90% on breathing room air) 7. Pneumothorax 8. Hyperventilation syndrome (including past history) 9. Poorly controlled hypertension 10. Unable to understand sputum induction 11. Inability to follow sputum induction instruction 12. Pregnant women 13. Unsuitable for participation by the decision of the responsible doctors 14. Over days after the start of TB treatment
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The results of AFB smear, culture, and TB PCR in (induced) sputum
- Secondary Outcome Measures
Name Time Method 1. Success rate of sputum induction and timing of expectoration 2. Condition and amount of sputum 3. Oxygen saturation before and after sputum induction 4. Adverse events