ROLE OF VATAPATRADI LEPA IN THE MANAGEMENT OF MUKHADUSHIKA w.s.r TO ACNE VULGARIS"

Phase 2

Not yet recruiting

Conditions: Other Procedures. Ayurveda Condition: (1) M, (2) ICD-10 Condition: L99||Other disorders of skin and subcutaneous tissue in diseases classified elsewhere. Ayurveda Condition: PIDAKA,

Registration Number: CTRI/2025/06/089022

Lead Sponsor: JAMMU INSTITUTE OF AYURVEDA AND RESEARCH

Brief Summary: *Mukhadushika’* is one of such diseases illustrated in *Ayurveda* which affects the beauty of the face. This diseases hasbeen described under *Kshudraroga* inthe classical text. *Acharaya Shusruta*first described *Mukhadushika* in *Kshudraroga* in *Nidaansthan* 13 /38 in *Chikitsasthana* 20/37 .It occurs due tovitiation of *kapha Dosha*, *Vata Dosha* and *Rakta Dhatu*.In *Mukhadushika* the eruption like *ShalmaliKantaka*.The common site of *Mukhadushika*is face, in which forehead,cheeks,nose, and chin are the prominent sites .

It can becoorelated with Acne Vulgaris in modern science . Acne Vulgaris is anincredibly common cutaneous inflammatory skin disorder in developed nation as well as in developing countries likeIndia . In this condition many teenagers, characterized by blockageof pilosebaceous duct and involves areaof skin where sebaceous glands are most numerous and active .However , with the rise inhormones, food sensitivities, digestive problems, toxic environments, stress,high carbohydrate diets, and mineral and vitamins deficiencies, acne plaguesall ages .

Topical Antibiotic therapy is recommended forits treatment but their chemical compounds creates adverse effects on the body,so natural non toxic medicines should be used to bring the skin into normal stateby treating problem like *Mukhadushika* .Acne Vulgaris develops as a result of hypersensitivityof the sebaceous glands to normal levels of circulating androgens. This processis further exacerbated by the presence of Cutibacterium acnes [ C acnes ]

In *Mukhadushika Saruja* (painfull), *Pidika*(eruption) are hallmarks of *Mukhadushika* .Vitiated *Dosha* get accumulated andobstruct the *Lomarupa* (pilosebaceousunit) causing localswelling and micro comedone formation .*Paka*(inflammation) of these elements leads to papules,pustules, and cyst formationwhich on rupture   cause *Vranavastu* (scar) formation. Allopathictreatments includes the use of topical retinoids, benzoyl peroxide , oralantibiotics, steroids , and oralisotretinoin . Although its use is limited by teratogenicity andother side effects. *Ayurveda* has agreat potential in the management of Acne vulgaris is reported. Two types of *Chikitsa* are explained in the managementof *Mukhadushika* i.e, *Shodhana* and *Shamanachikitsa*. *Shodhanachikitsa*includes *Vaman* ,*Virechana*, *Nasya*, *Jalaukavcharna* and *Shiravyadha*. *Shaman Chikitsa*includes various type of *lepa* andoral medication.

Inpresent study one such formulations of *lepa*which is given in *Sharangdharasamhitauttarkhand*11 /14-15 is *Vatapatradi lepa*(trial drug ) is taken to assess its efficacy on *Mukhadushika* w.s.r to Acne vulagaris and compared with *Shalmaliadi lepa* ( controlled).

·     *The word ‘Mukha’ means face or countenance and Dushika means face spoiler or eruption that configuresthe Mukh a(face)* .

  ·      The word *Mukhadushika* is derived from *Mukhamdushayathi Vivarnamkarothiiti Mukhadushika* means that which disfigures the *Mukha* along with causing discolouarion.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 30

Inclusion Criteria

Patients of age 16-30 yrs.
will be taken for study.
Patients representing signs and symptoms of Mukhadushika who will be willing to participate in study .
Subjects of both genders will be considered.

Exclusion Criteria

Patients with severe nodular acne.
Pregnancy and nursing women.
Acne caused by the dandruff will be excluded.
Patient having any systemic pathology.
Clinically infected lesion that require.
treatment with systemic antibiotics and or local antiseptic and or other treatment.
Patient on any other anti acne therapy.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
3.kandu	Baseline
1.Number of Pidika	Baseline
2.Area occupied by Pidika	Baseline
5.Paka	Baseline
6.Srava	Baseline
7.Vedana	Baseline
SUBJECTIVE CRITERIA:	Baseline
4.Daha	Baseline

Secondary Outcome Measures

Name	Time	Method
Number of Pidika	Area occupied by Pidika

Trial Locations

Locations (1): JAMMU INSTITUTE OF AYURVEDA AND RESERACH
🇮🇳
JAMMU, & KASHMIR, India
JAMMU INSTITUTE OF AYURVEDA AND RESERACH
🇮🇳JAMMU, & KASHMIR, India
Dr Shivani Mishra
Principal investigator
6006912792
shivanimishra5474@gmail.com